Purchase this article with an account.
G. Akiyama, T. Sakai, N. Kuno, E. Kimura, K. Okano, H. Kohno, M. Ozaki, H. Tsuneoka; Effect of Pigment Epithelium-Derived Factor-Impregnated Nanoparticles in P23H Transgenic Rat Retina. Invest. Ophthalmol. Vis. Sci. 2009;50(13):692.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the protective effect of intravitreal injection of pigment epithelium-derived factor-impregnated nanoparticles (PEDF-NPs) against photoreceptor degeneration in P23H transgenic rats.
Six-week-old P23H rats received an intravitreal injection of PBS, blank NPs, PEDF (2.5 µg) or PEDF-NPs (2.5 µg). Eyes were assessed by morphological and immunohistochemical analysis over the following 8 weeks.
Immunocytochemistry did not exhibit greater opsin preservation in PEDF-NPs-treated retinas, and a significantly higher number of photoreceptors, compared to blank NPs-treated retinas.
The results suggest that intravitreally injected PEDF-NPs did not prevent photoreceptor degeneration in the P23H rat retina.
This PDF is available to Subscribers Only