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T. Yoshikawa, N. Ogata, M. Wada, T. Otsuji, M. Matsuoka, K. Matsuyama, K. Takahashi; Age-Related Macular Degeneration in Patients With Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):943.
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Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are two of the major causes of adult blindness. The number of both types of patients is increasing. The aim of this study was to determine the clinical characteristics of DR patients with AMD.
A retrospective, consecutive case series. Twenty-six eyes of 25 type 2 diabetic Japanese patients with DR were studied. They were diagnosed as having exudative AMD and DR at Kansai Medical University, Takii Hospital between in 1999 to 2008. Patients with dry AMD, neovascular maculopathy associated with high myopia, no apparent DR and age <50 years were excluded. The clinical characteristics, e.g., gender, stage of diabetic retinopathy, and type of AMD, were determined.
The mean age of the patients was 71.0 years with a range 60 to 88 years. There were 23 men (92.0%) and 2 women (8.0%). In the 26 eyes, 2 (7.7%) were classified as mild nonproliferative DR, 7 (27.0%) as moderate nonproliferative DR, 16 eyes (61.5%) as severe nonproliferative DR, and 1 eye (3.8%) as proliferative DR. Fifteen eyes (57.7%) had received retinal photocoagulation to treat the diabetic retinopathy, and 11 eyes (42.3%) had not. None of the eyes had received grid pattern photocoagulation or photocoagulation for the microaneurysms in the macular region. Of the 26 eyes, 21 eyes (80.8%) were classified as neovascular AMD, 4 eyes (15.4%) as polypoidal choroidal vasculopathy (PCV), and 1 eye (3.8%) as retinal angiomatous proliferation (RAP). Among the eyes with neovascular AMD, 9 eyes (42.9%) were classified as predominantly classic choroidal neovascularization (CNV), 3 eyes (14.2%) were classified as minimally classic CNV, and 9 eyes (42.9%) were classified as occult with no classic CNV.
We found a higher percentage of DR male patients with AMD. The prevalence of PCV in DR patients was lower than that of Japanese patients without DR. Neovascular AMD was the most frequent type of AMD in patients with DR.
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