April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Peripapillary Nerve Fiber Layer Thickness in Exudative Age-Related Macular Degeneration in Japanese Patients
Author Affiliations & Notes
  • K. Yuda
    Opthalmology, Tokyo University, Tokyo, Japan
  • Y. Inoue
    Opthalmology, Tokyo University, Tokyo, Japan
  • Y. Tamaki
    Opthalmology, Tokyo University, Tokyo, Japan
  • Y. Yanagi
    Opthalmology, Tokyo University, Tokyo, Japan
  • Footnotes
    Commercial Relationships  K. Yuda, None; Y. Inoue, None; Y. Tamaki, None; Y. Yanagi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 944. doi:
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    • Get Citation

      K. Yuda, Y. Inoue, Y. Tamaki, Y. Yanagi; Peripapillary Nerve Fiber Layer Thickness in Exudative Age-Related Macular Degeneration in Japanese Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):944.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine the peripapillary retinal nerve fiber (RNFL) thickness in patients with two major forms of exudative age-related macular degeneration (AMD) in Japanese patients, i.e., typical AMD and polypoidal choroidal vasculopathy (PCV).

Methods: : This is a prospective, observational study. Consecutive one-hundred patients who visited outpatient macular clinic of the University of Tokyo Hospital and with unilateral exudative AMD were included. Peripapillary RNFL thickness was measured using three-dimensional fourier-domain optical coherence tomography (3D OCT-1000; Topcon Corp, Tokyo, Japan). The acquisition scan protocol used in this study acquires a set of three high-definition OCT images of the optic never head in a raster pattern covering a 6×6mm area with a scan density of 512×128 in ~3.5 sec (18,000 A scans/sec). Peripapillary map consisted of 3.4mm circle around the optic disk. Peripapillary RNFL thickness was automatically calculated by the software currently provided by the manufacturer (3D OCT-1000 PC software). Peripapillary RNFL thickness was measured for 6 areas; temporal, temporal-superior, temporal-inferior, nasal, nasal-superior, and nasal-inferior and the comparison was made between the affected eyes and fellow eyes. Paired t-test was used for comparing RNFL thickness between the affected eyes and fellow eyes.

Results: : RNFL thickness in the eyes with exudative AMD did not differ significantly from those in the fellow eyes. There was also no association between the size of the macular degeneration and the peripapillary RNFL thickness.

Conclusions: : There is no relationship between exudative AMD and peripapillary RNFL thickness in Japanese patients.

Keywords: age-related macular degeneration • nerve fiber layer • imaging/image analysis: clinical 
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