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M. E. Schneck, K. Bronson-Castain, M. A. Bearse, Jr., J. Neuville, S. Jonasdottir, B. King-Hooper, A. J. Adams; Adolescent Macular Thickness and Vascular Caliber in the Presence of Type 1 and Type 2 Diabetes. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1333.
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© ARVO (1962-2015); The Authors (2016-present)
To examine macular thickness and retinal vascular caliber and the relationship between the two in adolescents with type 1 and type 2 diabetes.
Thirty-two adolescents with type 1 diabetes (5.7 ± 3.6 yrs diabetes duration) and 15 adolescents with type 2 diabetes (2.1 ± 1.3 yrs) were examined. Twenty-six age-matched subjects without diabetes served as controls. Digital fundus photographs of the central 45 degrees of the retina were acquired and examined by a masked retinal specialist. All groups were without vascular lesions in either eye. The mean macular thicknesses in 37 hexagonal regions were derived from twelve radial scans, 6 mm long, centered at the fovea, using Stratus OCT 3. The average arteriolar and venular diameters within ½ to 1 disc diameter around the optic nerve were analyzed with IVAN (University of Wisconsin-Madison, WI) using the Parr and Spears’ algorithm. T-tests were used to compare the mean differences between groups and linear regression analysis was used to look for associations between macular thickness and vascular caliber.
The mean macular thickness of the type 2 group (243.4 ± 3.3 µm, Mean ± SE) was significantly (p < 0.03) thinner than that of the control group (253.7 ± 2.5 µm) but did not differ from the type 1 group (249.9 ± 2.4 µm). The mean venular caliber of the type 2 group (235.8 ± 5.9 µm) was significantly larger (p < 0.05) than the control group’s (219.6 ± 4.0 µm). The type 1 group (223.2 ± 4.1 µm) did not differ (p > 0.05) from either the type 2 or control groups. The mean arteriolar caliber of the type 1 (171.5 ± 3.2 µm) and type 2 (165.5 ± 4.0 µm) groups did not differ (p > 0.05) from that of the control group (172.1 ± 3.5 µm). Retinal thickness was positively correlated with arteriole caliber in the type 1 group (p < 0.01). There were no other significant associations.
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