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R. M. Feist, Jr., R. M. Feist, M. E. Tomlinson, T. L. Emond, G. McGwin, Jr.; Intravitreal Avastin Adjunctive Therapy Prior to Cataract Extraction in Eyes With Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1358.
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To evaluate the potential benefit of a single injection of intravitreal Avastin with cataract extraction. We hypothesized that Avastin administered a month prior to or during surgery would result in better postoperative outcomes in patients with diabetic macular edema.
Retrospective medical record review of twenty-six patients in a large multi-physician vitreoretinal clinic between January of 2006 and April of 2008. Inclusion criteria included eyes with diabetic macular edema, cataract, and intravitreal Avastin injection administered a month prior to or during cataract surgery, pre- and postoperative optical coherence tomography (OCT) and best-corrective visual acuity (BCVA) testing. Exclusion criteria included patients with cystoid macular edema, macular hole, aphakia, pseudophakia, retinal vein occlusion, and macular edema from any other retinal disorder.
The mean pre- and postop foveal thickness measurements were 265 and 297. The mean pre- and postop macular volume measurements were 7.41 and 7.90. The mean pre- and postop logmar BCVA was 0.7 and 0.54. Visual outcomes were generally good in this group of patients who had active diabetic retinopathy, with 73% (22 of 30 eyes) showing visual improvement at one month postop.
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