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J. Couceiro, S. Gonçalves, P. Fernandes, A. Coutinho, M. Silva, A. R. Figueiredo, M. Monteiro-Grillo, G. Miltenberger-Miltenyi; Analysis of the TCF7L2 Polymorphism rs7903146 in Diabetic Retinopathy Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1364.
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To analyze the frequency of the different alleles of rs7903146 polymorphism in patients with diabetic retinopathy (DR) vs. those without diabetic retinopathy.
This is a case control study which evaluated 75 patients with type 2 diabetes with at least 15 years of disease (age: 67.5 ± 7.5 ys; 41 males, 34 females). There were 41 cases of DR and 34 controls without DR. All patients underwent a complete clinical, ophthalmologic and laboratory evaluation. Analysis of polymorphism was done using PCR and RLFP. A group of 23 aged matched healthy individuals was also evaluated for this polymorphism.
The frequency of the T allele in the diabetic patients tended to be higher than in the healthy control group (68% vs. 52%; p NS). Patients with DR had a higher frequency of the T allele (70.7%) than patients without DR (64.7%) however this difference was not statistically significant.
Our preliminary results showed a tendency for a higher frequency of the T allele of the TCF7L2 polymorphism in diabetic patients vs. healthy controls. Besides, there was a trend towards increased prevalence of the T allele in DR patients. This tendency could be explained by the impaired insulin secretion in T allele carriers. The inclusion of more subjects in this study will help to further define the significance of these differences.
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