April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Analysis of the TCF7L2 Polymorphism rs7903146 in Diabetic Retinopathy Patients
Author Affiliations & Notes
  • J. Couceiro
    Ophthalmology,
    Hospital de Santa Maria, Lisbon, Portugal
  • S. Gonçalves
    Nephrology,
    Hospital de Santa Maria, Lisbon, Portugal
  • P. Fernandes
    Nephrology,
    Hospital de Santa Maria, Lisbon, Portugal
  • A. Coutinho
    Genomed - Diagnósticos de Medicina Molecular, Lisbon, Portugal
  • M. Silva
    Genomed - Diagnósticos de Medicina Molecular, Lisbon, Portugal
  • A. R. Figueiredo
    Ophthalmology,
    Hospital de Santa Maria, Lisbon, Portugal
  • M. Monteiro-Grillo
    Ophthalmology,
    Hospital de Santa Maria, Lisbon, Portugal
  • G. Miltenberger-Miltenyi
    Genomed - Diagnósticos de Medicina Molecular, Lisbon, Portugal
    Instituto de Medicina Molecular, Lisbon, Portugal
  • Footnotes
    Commercial Relationships  J. Couceiro, None; S. Gonçalves, None; P. Fernandes, None; A. Coutinho, None; M. Silva, None; A.R. Figueiredo, None; M. Monteiro-Grillo, None; G. Miltenberger-Miltenyi, None.
  • Footnotes
    Support  Sanofi-Aventis Grant
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1364. doi:
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    • Get Citation

      J. Couceiro, S. Gonçalves, P. Fernandes, A. Coutinho, M. Silva, A. R. Figueiredo, M. Monteiro-Grillo, G. Miltenberger-Miltenyi; Analysis of the TCF7L2 Polymorphism rs7903146 in Diabetic Retinopathy Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1364.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To analyze the frequency of the different alleles of rs7903146 polymorphism in patients with diabetic retinopathy (DR) vs. those without diabetic retinopathy.

Methods: : This is a case control study which evaluated 75 patients with type 2 diabetes with at least 15 years of disease (age: 67.5 ± 7.5 ys; 41 males, 34 females). There were 41 cases of DR and 34 controls without DR. All patients underwent a complete clinical, ophthalmologic and laboratory evaluation. Analysis of polymorphism was done using PCR and RLFP. A group of 23 aged matched healthy individuals was also evaluated for this polymorphism.

Results: : The frequency of the T allele in the diabetic patients tended to be higher than in the healthy control group (68% vs. 52%; p NS). Patients with DR had a higher frequency of the T allele (70.7%) than patients without DR (64.7%) however this difference was not statistically significant.

Conclusions: : Our preliminary results showed a tendency for a higher frequency of the T allele of the TCF7L2 polymorphism in diabetic patients vs. healthy controls. Besides, there was a trend towards increased prevalence of the T allele in DR patients. This tendency could be explained by the impaired insulin secretion in T allele carriers. The inclusion of more subjects in this study will help to further define the significance of these differences.

Keywords: diabetic retinopathy • clinical (human) or epidemiologic studies: risk factor assessment • genetics 
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