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S. De Cilla, S. Ranno, E. Carini, P. Fogagnolo, G. Ceresara, N. Orzalesi, L. Rossetti; Corneal Confocal Microscopy in Patients With Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1376.
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© ARVO (1962-2015); The Authors (2016-present)
to study the subbasal corneal plexus in patients with diabetic retinopathy (DR) treated or non-treated with panretinal Argon laser photocoagulation (ALP).
50 consecutive patients with DR and 50 age- and sex-mached normal controls were examined using Heidelberg Retina Tomograph (HRT), Rostock Cornea Module (RCM) by a masked well trained evaluator. Intraobserver agreement for image scores was calculated by means of intraclass correlation coefficient (ICC= 0.70= substantial agreement).The following subbasal plexus nerves parameters were considered: number per frame , tortuosity and reflectivity. Diabetic patients were divided into two groups, according to the presence of proliferative vs non proliferative retinopathy (classification of the ETDRS).
number per frame and reflectivity were significantly lower in diabetic patients as compared with controls (2.4±1 vs 2.9±0.8, P=0.01and 2.3±0.9 vs 2.6±0.9, P=0.04 respectively). Tortuosity was significantly higher in diabetic patients (2.5±0.9 vs 2.0±0.8, P=0.002). Number per frame of SCP (respectively 2,0±0,9 vs 2.9±0,9, P=0.001) and reflectivity (respectively 2,0±0.8 vs 2.6±0.7, P=0.003) were significantly lower in diabetic patients with proliferative retinopathy as compared with non proliferative retinopathy. Tortuosity was significantly higher in diabetic patients with proliferative retinopathy (2.2±0.8 vs 2.8±0.9, P=0.008). In the group of proliferative DR, patients treated with ALP had significantly lower subbasal nerves number as compared with non-treated patients (p=0,01).
diabetic retinopathy may induce remarkable changes in the SCP. There is a difference between proliferative and non proliferative retinopathy and in the former group between ALP treated and non-treated patients.
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