April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Evaluation of Nepafenac Treatment of Cystoid Macular Edema
Author Affiliations & Notes
  • C. Chen
    Ophthalmology, UT Southwestern Ophthalmology Department, Dallas, Texas
  • Y. He
    Ophthalmology, UT Southwestern Ophthalmology Department, Dallas, Texas
  • Footnotes
    Commercial Relationships  C. Chen, None; Y. He, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1379. doi:
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    • Get Citation

      C. Chen, Y. He; Evaluation of Nepafenac Treatment of Cystoid Macular Edema. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1379.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the effectiveness of Nepafenec 0.1% treatment of cystoid macular edema (CME) in the improvement of visual acuity and reduction of foveal retinal nerve fiber layer (RNFL) thickness.

Methods: : This retrospective, interventional, consecutive case series was conducted at UT Southwestern Clinic and Parkland Memorial Hospital in Dallas, TX from January 2007 to December 2008, of patients with a new diagnosis of CME treated initially with nepafenac alone or in combination with topical steroids. Data on pre- and post-treatment best corrected Snellen visual acuity and foveal retinal thickness measured by optical coherence tomography (OCT) was obtained; exclusion criteria included prior treatment with posterior subtenon or intravitreal steroid agents.

Results: : Eighteen patients (mean age 71.1 years, range 51 to 89 years, 39% male) treated with nepafenac (8 alone, 1 in combination with loteprednol etabonate 0.5%, 9 with prednisolone acetate 1%) for pseudophakic or idiopathic CME were evaluated. Mean acuity improved from 20/82 to 20/43 after treatment (P=0.0010) with a mean improvement of 2.1 Snellen lines. Foveal retinal thickness was 383.6 and 254.9 microns before and after treatment, respectively (P=0.0004), with a mean reduction of 129 microns. Average treatment duration was 9.4 wks.

Conclusions: : This study suggests that Nepafenac 0.1% alone or in combination with topical steroids is effective in the treatment of CME in the improvement of visual acuity and reduction of foveal retinal thickness.

Keywords: macula/fovea • edema • retina 
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