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D. Thapa, A. Fleck, V. Lakshminarayanan, W. R. Bobier; Higher Order Aberrations and Refractive Error. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1557.
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© ARVO (1962-2015); The Authors (2016-present)
To determine if higher order aberrations (HOAs) vary with respect to magnitudes of hyperopia in a preschool population. Secondly to determine if HOAs are correlated between the eyes.
Images taken from refractive assessments of a preschool population using a prototype of the Welch Allyn SureSight were reanalyzed in order to allow measures of ocular aberrations. Measures from the cyclopleged eyes of 170 children (mean age 4.16 years ±1.18SD, range 3 to 6 years) were compared with existing measures of cyclopleged retinoscopy. The population showed a mean spherical equivalent of 1.66D±1.11SD and average astigmatism of 0.36D±0.38SD. Subjects were classified as, emmetropic (range -0.5 to +0.5D), low hyperopic (+0.5 to +2D) and high hyperopic (+2D or more) based on spherical equivalent. Zernike coefficients at 5 mm pupil size were calculated using MATLAB program. Total Root-mean-square (RMS) values from 3rd to 8th order, Total Coma (TC), Total Trefoil (TT) and Total Spherical Aberration (TSA) were analyzed.Pearson Correlation coefficient (r) was calculated to examine the correlation between the HAOs and refractive error and correlation of HOAs between right and left eyes.
Mean Total RMS for right and left eyes were 0.31±0.16 and 0.32±0.19 µm, mean TC 0.20±0.14 and 0.20±0.16 µm, mean TT 0.14±0.09 and 0.14±0.10 µm, and mean TSA 0.07±0.08 and 0.08±0.08 µm respectively. No significant differences in HOAs between right and left eyes were found (p>0.05). The Pearson correlation coefficient between right and left eyes for Total RMS was 0.813 (p<0.01), for TC 0.709(p<0.01), for TT 0.409(p<0.01) and for TSA 0.78(p<0.01). Mean Total RMS for emmetropic children was 0.28±0.09µm, for low hyperopic 0.31±0.16 µm and for high hyperopic 0.35±0.23 µm. No significant difference (p>0.05) in HOAs between different refractive error groups was found. The Pearson correlation coefficient between Total RMS and refractive error was r= 0.11 (p= 0.17), between TC and refractive error r= 0.08 (p=0.27), between TT and refractive error r = 0.13 (p=0.09) and between TSA and refractive error r = 0.04 (p=0.56).
Significant associations were found between right and left eyes of preschool children for total RMS, TC and TSA and a weak association was found for TT, No correlation was found between HOAs and refractive error. Suggesting that, HOAs may not be valid predictor of the refractor error.
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