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E. M. Mohamed, J. C. Wojtowicz, W. R. Bowman, D. Cavanagh, V. Mootha, S. Verity, J. P. McCulley; Corneal Thickness Association With Ocular and Corneal Wavefront Aberrations. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1566.
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Despite numerous efforts to measure wavefront aberrations in normal and anomalous eyes or in eye diseases using several wavefront techniques, complete knowledge of the sources of higher-order aberrations (HOAs) is far from established. As a dominant structure in determining the refractive power of the eye, the cornea was found to be a critical part in contributing to wavefront aberrations in the whole eye. The aim of our study is to investigate the association of central and peripheral corneal thickness (CCT) and wavefront aberrations in the anterior cornea, posterior cornea and the whole eye in myopia.Setting: University of Texas, Southwestern medical center, Dallas, Texas, USA
64 eyes of 64 subjects were tested for wavefront aberrations in the anterior and posterior corneal surface with Pentacam and with a wavefront aberrometer for ocular wavefront aberrations (Wavescan, Visx, Inc.). The central and peripheral CCT were measured with the pentacam. Relationships between the wavefront aberrations and peripheral and central CT were analyzed.
Only one posterior corneal Zernike aberrations was significantly correlated with the central corneal thickness which is coma (Z3-1) (r =-0.25, p=0.05). Three posterior corneal Zernike aberrations were significantly correlated with the peripheral corneal thickness, including posterior tilt (Z11)(r=0.28, p=0.02), posterior tilt (Z1-1)(r=0.3 ,p=0.005) and posterior (Z2 0)(r=0.26, p=0.04). As for ocular wave aberrations, No Zernike aberrations were significantly correlated with either central or peripheral corneal thickness. Also,there is statistically significant correlation between age and astigmatism,corneal spherical aberrations 4th & 6th order.
Central and peripheral corneal thickness were weakly associated with either anterior or posterior corneal wavefront aberrations. There was no association between Central and peripheral corneal thickness and ocular wavefront aberrations.
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