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A. Loewenstein, J. Ferencz, Y. Lang, I. Yeshurun, A. Pollack, R. Siegal, J. Karp, T. Lifshitz; Multi-Center Study of a New Home AMD Perimeter, Based on Preferential Hyperacuity, for Early Detection of CNV. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1660.
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A new home Macular Perimeter (HMP), based on the technology of preferential hyperacuity perimetry, was recently developed for the purpose of monitoring AMD patients. The aim of this study was to evaluate the sensitivity and specificity of this device in detection of CNV.
Patients with intermediate AMD or recent (developed within 2 months) CNV , performed an HMP examination and underwent biomicroscopy, color stereoscopic photography or fluorescein angiography. Grading, masked to the HMP results, was performed by two retina specialists.
77 patients were enrolled to the study. Of 43 patients with Intermediate AMD, 36 were true positive on the HMP, yielding a specificity of 84% (95% [CI] ±10%). Of 34 CNV patients, 29 were true positive on the HMP, yielding a sensitivity of 85% (95% [CI] ±12%). Sensitivity was not significantly different for sub-foveal (n=18) and non subfoveal (n=16) lesions (CHI-square test, p = 0.53), nor for occult (n=25) or classic (n=8) lesions (CHI-square test, p = 0.81).
The HMP has high specificity and sensitivity in differentiating CNV from intermediate AMD eyes, with a sensitivity that is independent of location or type of CNV lesion. At home this new diagnostic device can be used frequently. It therefore holds promise for earlier detection of CNV and better final outcome following treatment.
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