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C. L. Shields, A. Ramasubramanian, A. Thangappan, K. Hartzell, J. A. Shields; Chemoreduction for Group E Retinoblastoma in 76 Eyes. Invest. Ophthalmol. Vis. Sci. 2009;50(13):1688.
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To evaluate the success of chemoreduction for group E retinoblastoma (Rb).
Retrospective chart review
Of the 64 eyes in the chemoreduction (CRD) group 25% were salvaged with CRD alone and 20% with CRD and therapeutic [standard dose] external beam radiation (T-EBRT), while 34% were enucleated following CRD alone and 20% following CRD+T-EBRT. Of the 12 eyes in the CRD + prophylactic [low dose] external beam radiation (P-EBRT) group, 83% were salvaged with CRD+P-EBRT, while 17% were enucleated and none required T-EBRT.
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