April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Longitudinal Relationships Between Macular Pigment and Serum Lutein in Patients Enrolled in the CARMA Clinical Trial (Carotenoids and Co-antioxidants in Age-Related Maculopathy)
Author Affiliations & Notes
  • S. Beatty
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • M. Stevenson
    Ophthalmology Department, Queen's University Belfast, Belfast, United Kingdom
  • J. M. Nolan
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • J. Woodside
    Ophthalmology Department, Queen's University Belfast, Belfast, United Kingdom
  • The CARMA Study Group
    Macular Pigment Research Group, Waterford Institute of Technology, Waterford, Ireland
  • U. Chakravarthy
    Ophthalmology Department, Queen's University Belfast, Belfast, United Kingdom
  • Footnotes
    Commercial Relationships  S. Beatty, Educational grant from Dr Mann Pharma, F; Bausch and Lomb, C; Bausch and Lomb, R; M. Stevenson, None; J.M. Nolan, None; J. Woodside, None; U. Chakravarthy, Educational grant from Dr Mann Pharma, F; Bausch and Lomb, C; Bausch and Lomb, R.
  • Footnotes
    Support  Bausch & Lomb
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1719. doi:
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      S. Beatty, M. Stevenson, J. M. Nolan, J. Woodside, The CARMA Study Group, U. Chakravarthy; Longitudinal Relationships Between Macular Pigment and Serum Lutein in Patients Enrolled in the CARMA Clinical Trial (Carotenoids and Co-antioxidants in Age-Related Maculopathy). Invest. Ophthalmol. Vis. Sci. 2009;50(13):1719.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report on the relationships between estimates of macular pigment measured by Raman spectroscopy and serum lutein (L) in patients enrolled in the CARMA study (Carotenoids and Co-antioxidants in Age-Related Maculopathy).

Methods: : CARMA is a randomised double-masked prospective trial of L, zeaxanthin (Z), and co-antioxidants zinc, copper, vitamin E and vitamin C (Active; A) versus placebo (P). A total of 433 participants were randomised to A or P in two clinical centres (Belfast, Northern Ireland and Waterford, Republic of Ireland). Serum antioxidants were measured at every visit. Raman counts (RC) were obtained by spectroscopy. A general linear model was used to construct an analysis of covariance between RC and log serum L within patients across time.

Results: : Mean change in RC from baseline at 12 months was +26 in the A group, whereas in the P group a steady decline was observed culminating in a mean fall to -61 counts. This difference was highly significant (p=0.006). In the longitudinal analysis conducted without reference to treatment assignment, a ten-fold increase in serum L resulted in a positive differential of +70 RC.

Conclusions: : Supplementation with L and Z and co-antioxidants arrested the decline in RC observed over time in study eyes of participants at high risk of progression to late AMD .

Clinical Trial: : www.ISRCTN.org ISRCTN94557601

Keywords: age-related macular degeneration • macular pigment • antioxidants 
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