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A. Ferreras, P. Calvo, P. Fogagnolo, A. B. Pajarin, M. Figus, I. Pinilla; Reproducibility of Peripapillary Retinal Nerve Fiber Layer Thickness Measured With Spectral Domain Optical Coherence Tomography in Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2257.
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To determine the reproducibility of peripapillary retinal nerve fiber layer (RNFL) parameters measured with high definition (HD) spectral domain optical coherence tomography (OCT) in healthy eyes.
Forty-five healthy individuals were prospectively selected. Only one eye was randomly included in the study. All participants had intraocular pressure less than 21 mmHg and normal standard automated perimetry. Peripapillary RNFL thickness was measured using the optic disc cube 200x200 scan protocol of the Zeiss Cirrus HD-OCT 3 times on the same day. Left eye data were converted to a right eye format. The same operator performed all scans with the same device. Intraclass correlation coefficient (ICC), coefficient of variation (COV), and test-retest variability were calculated for RNFL thickness at each of the 12 clock-hour positions, quadrants and average thickness.
Mean age was 52.8±11.7 years. The ICC was higher than 0.92 for all OCT parameters. The 7 o’clock segment thickness presented the highest ICC (0.98), while the 9 o’clock segment thickness had the lowest ICC (0.91). The COV ranged from 2.5% (average thickness) to 6.4% (2 o’clock segment thickness). Test-retest variability was lower than 13 µm for all clock-hour positions. For quadrant thickness, test-retest variability ranged from 4.3 µm (temporal quadrant thickness) to 7.4 µm (superior quadrant thickness), and for RNFL average thickness was 4.6 µm.
The reproducibility of peripapillary RNFL thickness measurements acquired with Cirrus HD-OCT was excellent. Variability was somewhat higher for clock-hour segments than for quadrants and RNFL average thickness.
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