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J. Hong, S. Park, K. Sung, H. Hong, M. Kook; Reproducibility of Retinal Nerve Fiber Layer Thickness Measurement Using Spectral Domain Optical Coherence Tomography (Spectral OCT SLO). Invest. Ophthalmol. Vis. Sci. 2009;50(13):2263.
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© ARVO (1962-2015); The Authors (2016-present)
Different scan circle location of peripapillary retinal nerve fiber layer thickness (RNFL) measurement may be a source of test-retest variability in conventional time-domain OCT. The purpose of this study was to test the reproducibility of RNFL thickness measurement with retest mode of Spectral OCT SLO tracking system.
27 glaucomatous and 30 healthy eyes were scanned three times with 10 minutes interval using retest mode of RNFL thickness measurement in Spectral OCT SLO at same visit by well-trained single operator (Intra-session reproducibility). All healthy subjects were scanned 3 days later with same protocol (Inter-session reproducibility). Standard deviation (SD), coefficient of variation (CV), intraclass correlation coefficient (ICC) of RNFL thickness were calculated in average and 4 quadrants.
Intra-session SD, CV and ICC of average RNFL thickness were 2.0microns, 1.9% and 0.98 in glaucoma group, 2.4microns, 2.0% and 0.89 in healthy group. Inter-session SD, CV and ICC of average RNFL thickness were 2.6microns, 2.2% and 0.87 in healthy group. Nasal quadrants showed the least reproducibility among 4 quadrants.
RNFL thickness assessed by retest mode of Spectral OCT SLO showed excellent intra- and inter-session reproducibilities. Retest mode of RNFL thickness measurement in spectral domain OCT employing SLO tracking system may be helpful for reducing test-retest variability originated from operator scan circle placement.
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