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P. J. Mackenzie, H. Pham, N. G. Stouthidis, S. L. Mansberger, S. K. Gardiner, C. F. Burgoyne; Peripapillary HRT Reflectance Changes in Non-Human Primate Experimental Glaucoma. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2785.
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To examine peripapillary reflectance changes on scanning laser ophthalmoscope (SLO) images in non-human primate (NHP) experimental glaucoma.
HRT reflectance images were obtained from both eyes of NHPs at baseline (BSLN) and every two weeks following laser in one eye to elevate intraocular pressure through the onset and/or progression of topographic change (END). Pairs of reflectance images (comparison pairs: BSLN - END) from both the normal (NORM; n=27) and glaucomatous, (GON; n=25) eyes were presented in randomized order to 2 masked glaucoma specialists on 3 occasions. Within each pair, the optic disc was masked to remove information about cupping and the reviewers rated the presence or absence of a change in the extent of: 1) a ring of hyperreflectance immediately surrounding the disc margin and; 2) an outer ring of hyporeflectance. For each pair, and each reviewer, "change" required the identification of change on all three occasions.
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Peripapillary reflectance changes commonly occur in the NHP experimental glaucoma model. The relationship of this finding to underlying peripapillary scleral deformation and its occurrence in human glaucoma are currently under study.
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