April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Efficacy of 10% Povidone Iodine Application in Reducing the Conjunctival Bacterial Load of Patients Undergoing Cataract Surgery
Author Affiliations & Notes
  • H. Mino de Kaspar
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Ophthalmology Department, School of Medicine, Stanford, California
  • M. Rajab
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • L. He
    Ophthalmology Department, School of Medicine, Stanford, California
  • Y. Yactayo-Miranda
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • M. M. Nentwich
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • A. Gandorfer
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • C. Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • M. Grueterich
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • A. Kampik
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • Footnotes
    Commercial Relationships  H. Mino de Kaspar, None; M. Rajab, None; L. He, None; Y. Yactayo-Miranda, None; M.M. Nentwich, None; A. Gandorfer, None; C. Haritoglou, None; M. Grueterich, None; A. Kampik, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 2899. doi:
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      H. Mino de Kaspar, M. Rajab, L. He, Y. Yactayo-Miranda, M. M. Nentwich, A. Gandorfer, C. Haritoglou, M. Grueterich, A. Kampik; Efficacy of 10% Povidone Iodine Application in Reducing the Conjunctival Bacterial Load of Patients Undergoing Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2009;50(13):2899.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the efficacy of 10% povidone iodine (PVI) drops in the reduction of conjunctival load, given before cataract extraction.

Methods: : In this prospective study on in- and out-patients undergoing cataract surgery, participants were randomized into Group 1 (standard pretreatment with 1% PVI irrigation) and Group 2 (additional pretreatment with 10% PVI eye-drops) after consent and according to the protocol approved by the Institutional Review Board. All 70 outpatients received neomycin eye drops the hour before surgery while all 91 in-patients received four times one drop of neomycin the day prior to the intervention. During preoperative preparation, all eyes were first disinfected periorbitally with 10% PVI. In Group 1 eyes were irrigated subsequently with 10mL of 1% PVI just before surgery, while in Group 2 patients were given (in addition to the treatment of Group 1) 3 drops of 10% PVI 10 minutes before surgery. Conjunctival specimens were collected and inoculated in thioglycolate broth at the following time-points: T1 - upon arrival in the operate room, T2 - after 1% PVI irrigation, before surgery, T3 - post-surgery. All culture growth was identified and the results compared between groups (see tables).

Results: :

Conclusions: : The addition of 3 drops of 10% PVI before surgery to a prophylactic regime consisting of antibiotic application and irrigation with 10 mL of 1% PVI did not result in significant additional benefits in the reduction of conjunctival bacterial load in both in- and out-patients.

Keywords: conjunctiva • cataract • clinical research methodology 
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