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W. Nam, I. A. Barbazetto, R. T. Smith, S. Chang; Correlation of Macular Volume and Central Foveal Thickness With Structural Changes Observed by Spectral Domain Oct Imaging. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3242.
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© ARVO (1962-2015); The Authors (2016-present)
3D spectral optical coherence tomography (OCT) imaging allows for more precise macular volume and macular thickness assessment. The aim of this study is to compare changes in macular volume and central macular thickness measured by spectral OCT imaging to structural changes of the macula.
In a retrospective study 135 serial OCT images (Cirrrus OCT, Carl Zeiss Meditec, Dublin, CA) of 18 patients (M:F=16:9, mean age 72) treated for macular edema with intravitreal anti-VEGF therapy were analyzed. Percentages of change in macular volume, central macular thickness and average macular thickness were compared and correlated to the presence of cystic changes, subretinal fluid, combined changes (cystic changes and subretinal fluid) and centric or eccentric maximal retinal elevation.
Percentage changes of central macular thickness showed greater variability than macular volume or average macular thickness (figure 1). Percent change of macular volume and central subfield thickness were more likely to be correlated in patients with centric maximal retinal elevation(r=0.8048) than eccentric maximal retinal elevation(r=0.6898). In regard to structural macular changes, the macular volume and the central subfield macular thickness were less likely correlated in combined type(r=0.5315) than cystic changes(r=0.7769) or subretinal fluid(r=0.7448). No statistical difference between OCT images taken by photographers were detected when comparing 10 images taken minutes apart by two different photographers(P>0.05).
Central subfield thickness appears to change more frequently during treatment for macular edema when compared to macular volume or central macular thickness. The central subfield thickness and the macular volume could be used independently as an indicator for macular change in centric maximal retinal elevation. In case of eccentric maximal retinal elevation additional clinical correlation may be required.
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