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H. Saito, A. Tomidokoro, M. Araie, M. Hangai, S. Ohkubo, M. Shirakashi, K. Sugiyama, A. Iwase, H. Abe, N. Yoshimura; Peripapillary Retinal Nerve Fiber Layer Thickness Measurement by Spectral Domain Optical Coherence Tomography, Scanning Laser Polarimetry and Confocal Scanning Laser Ophthalmoscopy in Normal Subjects. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3254.
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© ARVO (1962-2015); The Authors (2016-present)
To compare average peripapillary retinal nerve fiber layer thickness (avg RNFLT) determined by spectral domain optical coherence tomography (SD-OCT, 3D-OCT1000), scanning laser polarimetry (GDx with variable corneal compensation [VCC] and enhanced corneal compensation [ECC]) and confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomography [HRT] II).
In 164 eyes of 164 normal subjects, avg RNFLT was determined with SD-OCT, GDx VCC/ECC, and HRT II, and was correlated with each other. The peripapillary area was divided into 6 sectors for regional analysis.
Subjects’ age averaged 51.1±16.2 (range: 21~77) years old and spherical equivalent error (SE) -0.63±1.64 (-5.75~2.88) diopters (D). In 135 eyes of 135 subjects with reliable SD-OCT and GDx results, avg RNFLT by SD-OCT at a 3.4mm diameter significantly correlated with the TSNIT average of GDx VCC (Rs=0.48, P<0.0001) Avg RNFLT of each sector significantly correlated between the two devices (Rs=0.35~0.54, P<0.0001), although the ratio of measurement values (TSNIT average [GDx VCC]/ avg RNFLT [SD-OCT]) varied significantly among the sectors (0.40~0.69, P<0.0001). The results were similar regarding correlation between SD-OCT and GDx ECC. When the subjects were divided into half by an SE of -0.5D, there was no significant difference in correlation in avg RNFLT by SD-OCT and GDx VCC/ECC between the two groups. However, avg RNFLT by SD-OCT did not significantly correlate with those by GDx in the temporal superior and inferior sectors in myopic eyes (SE≤-0.5D), whereas significant correlation was seen in all sectors in non-myopic eyes. In 164 eyes of 164 subjects with reliable SD-OCT and HRT II results, avg RNFLT by SD-OCT did not significantly correlate with the mean RNFLT by HRT II (Rs=0.16, P=0.08).
RNFLT measurements by SD-OCT and GDx VCC/ECC significantly correlated with each other in normal subjects. However, the degree of correlation was not high enough and RNFLT values were not interchangeable. No significant correlation was seen between RNFLT measured by SD-OCT and HRT II.
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