Purchase this article with an account.
I. Pires, L. Duarte, S. Nunes, I. Pereira, R. Bernardes, J. Cunha-Vaz; Microaneurysms Formation Rate as a Predictor of DR Progression to CSME Needing Photocoagulation in Nonproliferative Retinopathy in Diabetes Type 2. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3270.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To examine the relation between microaneurysms (MA) formation rate using a new semi-automatic method based on color-fundus photographs, and DR progression to clinically significant macular edema (CSME) needing photocoagulation in a 10-years follow-up period of type 2 diabetic patients with nonproliferative retinopathy.
Seventy-seven patients/eyes with type 2 diabetes and nonproliferative retinopathy were followed-up for 2 years as controls of diabetic retinopathy clinical trials and underwent ophthalmological examinations every 6 months, including stereoscopic color fundus photography and were maintained under good metabolic control. All patients were followed-up for the next 8 years by conventional general and ophthalmological care accomplishing a total follow-up of 10 years. Photocoagulation for CSME was performed according to well defined guidelines and was considered the study main end-point. Using a new semi-automatic method for MA earmarking, which takes into account the exact location of each MA, the MA formation rate for the 2 first years of follow-up was computed (number of new MA appearing per year).
At the end of the 10-year period of follow-up, 12 of the 77 patients had developed CSME needing photocoagulation.A MA formation rate of 8.0±10.0 MA/year (Mean±SD) was found in these 12 patients’ eyes, being it statistically higher than for patients’ eyes that did not develop CSME (mean±SD: 1.8± 2.3) (p=0.003). The CSME patients presented also a higher HbA1C level at baseline (mean±SD: 8.1±1.1) compared to the remaining patients (mean±SD: 7.2±0.9; p=0.034).
A high MA formation rate earmarked on color-fundus photographs appears to be a good predictor of DR progression to CSME needing photocoagulation in type 2 diabetic patients with nonproliferative retinopathy.
This PDF is available to Subscribers Only