April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Influence of Pupil Dilation on Retinal Nerve Fiber Layer Measurements With Spectral Domain OCT
Author Affiliations & Notes
  • G. C. Massa
    Ophthalmology, University of Campinas, Campinas, Brazil
  • V. G. Vidotti
    Ophthalmology, University of Campinas, Campinas, Brazil
  • F. Cremasco
    Ophthalmology, University of Campinas, Campinas, Brazil
  • A. P. C. Lupinacci
    Ophthalmology, University of Campinas, Campinas, Brazil
  • V. P. Costa
    Ophthalmology, University of Campinas, Campinas, Brazil
  • Footnotes
    Commercial Relationships  G.C. Massa, None; V.G. Vidotti, None; F. Cremasco, None; A.P.C. Lupinacci, None; V.P. Costa, None.
  • Footnotes
    Support  Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3331. doi:
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      G. C. Massa, V. G. Vidotti, F. Cremasco, A. P. C. Lupinacci, V. P. Costa; Influence of Pupil Dilation on Retinal Nerve Fiber Layer Measurements With Spectral Domain OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3331.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the influence of pupil dilation on retinal nerve fiber layer (RNFL) measurements with Spectral Domain OCT.

Methods: : 29 healthy individuals and 26 glaucoma patients underwent RNFL measurements with the Cirrus HD-OCT Model 4000 (Carl Zeiss, Med Tec Inc, Dublin, CA, USA) pre and 30-40 minutes after pupil dilation with one drop of tropicamide 1%. Average thickness, quadrant thickness and clock-hour thickness measurements were compared with the paired Student’s t test. We also compared the quality scores of the images obtained pre and post pupil dilation.

Results: : Mean ages in the glaucoma and control groups were 58.3 + 13.4 years and 41.6 + 16.4 years, respectively (p<0.001). Mean MD values were -6.96 + 6.31 dB in the glaucoma group and -1.26 + 0.79 dB in the control group (p<0.001). There was no statistically significant difference between mean quality scores obtained pre and post dilation neither in the glaucoma group (p=0.232) nor in the control group (p=0.380). There was no statistically significant difference between mean RNFL measurements obtained pre and post pupil dilation neither among normal individuals (p>0.05), nor among glaucoma patients (p>0.05). Mean RNFL measurements obtained in the glaucoma group were significantly lower than those obtained in the control group (p<0.001).

Conclusions: : The results of this study indicate that RNFL measurements obtained with Spectral Domain OCT are not influenced by pupil size.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc • imaging/image analysis: clinical 
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