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F. Di Matteo, M. Fiori, P. Bettin, M. Gagliardi, S. Bianchi Marzoli, L. Pierro, R. G. Carassa; Comparison of Retinal Nerve Fiber Layer Thickness Measurements Using Fourier-Domain and Time-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3338.
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To compare Fourier-Domain and Time-Domain Optical Coherence Tomography (OCT) measurements of peripapillary retinal nerve fiber layer (RNFL) thickness.
This study involved 41 healthy volunteers. One eye was randomly chosen for study purposes. All subjects underwent a complete ophthalmological evaluation and optic nerve head imaging with Fourier-Domain OCT (OPKO Spectral OCT/SLO, software version 1.76, Ophthalmic Technologies Inc, Toronto, Canada) using the "RNFL" protocol and Time-Domain OCT (Stratus OCT, software version 4.0, Carl Zeiss Meditec Inc, Dublin, CA, USA) using the "Fast RNFL Thickness 3.4" protocol. Mean values were compared by paired t-test. The agreement between Spectral OCT/SLO and Stratus OCT was evaluated by Bland-Altman plots.
Mean age was 38 ± 8.3 years. Average RNFL thickness with Spectral OCT/SLO (109.17 µm) was significantly higher than Stratus OCT (101.17 µm). Spectral OCT estimates were also higher than Stratus OCT in the superior (129.61 µm vs. 127.12 µm respectively, p=0.14), temporal (75.78 µm vs. 69.56 µm, p<0.001), inferior (134.51 µm vs. 127.93 µm, p<0.001), nasal (96.63 µm vs. 79.76 µm, p<0.001) sectors. The difference between Spectral OCT/SLO and Stratus OCT estimates of the average RNFL thickness was within ± 12 µm in 95% of the patients.
Spectral OCT/SLO RNFL measurements were moderately higher than Stratus OCT in the inferior, temporal and superior sectors. A more significant overestimation was found in the nasal sector.
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