April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Physiologic PET/CT Imaging of Choroidal Melanoma: Before and After Plaque Brachytherapy
Author Affiliations & Notes
  • K. J. Chin
    The New York Eye Cancer Center, New York, New York
  • P. T. Finger
    Ophthalmology,
    The New York Eye Cancer Center, New York, New York
    Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
  • Footnotes
    Commercial Relationships  K.J. Chin, None; P.T. Finger, None.
  • Footnotes
    Support  The EyeCare Foundation, Inc., New York City, http://eyecarefoundation.org
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3376. doi:
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      K. J. Chin, P. T. Finger; Physiologic PET/CT Imaging of Choroidal Melanoma: Before and After Plaque Brachytherapy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3376.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report on PET/CT imaging findings of uveal melanomas with positive standardized uptake values (SUV) before and after plaque brachytherapy.

Methods: : Patients were diagnosed with choroidal melanoma by ophthalmoscopy, ultrasound, and fundus photography with angiography. Patients eligible for ophthalmic plaque brachytherapy underwent pre-operative whole body PET/CT to evaluate their local tumor and for systemic metastasis. Choroidal melanomas with standardized uptake values (SUV) > 2.0 were included in this study. Plaque brachytherapy (pd-103) was delivered over 7 continuous days. Choroidal melanoma SUV’s were periodically re-evaluated over the following 36 months.

Results: : Of the 200 patients who underwent whole body PET/CT for initial staging prior to brachytherapy, 22 (11%) were found to have a positive intraocular SUV. Of these, 13 were able to undergo interval follow-up PET/CT. There were 10 females and 3 males with a mean age of 67.5 years (range 32-85). There was 1 T2, 8 T3 and 4 T4 melanomas by 7th Edition AJCC-UICC criteria. Mean apical thickness was 8.9 (range 3-12.3) mm and mean largest tumor diameter was 15.4 (range 13-19.9) mm. Mean initial SUV was 3.6 (range 2.1-7.3) and patients were followed for a mean 15.5 (range 6-36) months. The mean time to tumor extinguishing (SUV=0) was 10.3 (range 6-17) months. Despite tumor extinguishing on PET/CT, there was one case of an atypical tumor recurrence (at 2 years) and one case of metastatic disease (at 21 months).

Conclusions: : PET/CT imaging offers a physiological assessment of glucose metabolism in choroidal melanoma. This study demonstrates that PET/CT offers a method to determine metabolic activity (or lack thereof) after treatment.

Keywords: melanoma • uvea • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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