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A. A. Moshfeghi, T. Hernandez-Boussard, R. Charalel, J. M. Morton, D. M. Moshfeghi; The Incidence of Endophthalmitis in Neonates Is Declining. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3563.
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To determine the incidence of neonatal endogenous endophthalmitis in the U.S.A. between 1998-2006 and associated risk factors.
ICD-9 codes for endophthalmitis, sepsis, and suspected endophthalmitis risk factors in hospitalized infants and neonates were searched in the National Inpatient Sample, a 20% representative sample of all hospital discharges in the United States.
Of 35.4 million live births in 1998, 316 newborns were identified with endophthalmitis (rate/100,000 live births, 0.0089%). The incidence of endophthalmitis decreased at a rate of 6% per year (p = 0.01130) over the time period between 1998 and 2006. Of 40.1 million live births in 2006, only 179 newborns were identified with endophthalmitis (rate/100,000 live births, 0.0045%) by comparison. Neonates with endophthalmitis were more likely to have systemic bacteremia (p < 0.0001, odds ratio 21.114), Candidemia (p < 0.0001, odds ratio 2.356), to have a birth weight of less than 1500g (p < 0.0001, odds ratio 1.215), and retinopathy of prematurity (p < 0.0001, odds ratio 2.052).
We demonstrated the importance of retinopathy of prematurity, low birth weight, bacteremia, and Candidemia as risks for endophthalmitis development in infants, which appears to be decreasing in recent years.
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