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A. Quijada, D. Salom, S. Garcia-Delpech, P. Udaondo, M. Diaz-Llopis; Aqueous Humor Pigment Epithelium-derived Factor Levels in Patients With Acute Anterior Uveitis. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3575.
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Pigment epithelium-derived factor (PEDF) is an anti-angiogenic/neurotropic dual functional factor, and recently it was also shown to mediate anti-oxidative action. The purpose of this study was to evaluate the levels of PEDF in the aqueous humor in eyes with acute anterior uveitis (AAU).
A prospective, comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with AAU. The level of PEDF was determined with a commercially available enzyme-linked immunoabsorbent assay kit. The control group comprised 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases.
The concentration of PEDF in aqueous humor was markedly higher in patients with UUA than in control subjects (Mann-Withney U test, P< 0.001). The level of PEDF was 6291637.70 ± 8564836.48 (mean ± SD) pg/ml in eyes with UUA and 449178.10 ± 158670.19 pg/ml in the eyes of the control group.
The aqueous humor PEDF level is increased in eyes with AAU, and may be increased as a countersystem against inflammation in AAU.
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