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S. Modjtahedi, B. Modjtahedi, C. Chiou, L. Morse, D. Telander, S. Park; Comparison of Central and Peripheral Macular Thickness Between Stratus and Fourier-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3792.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the central and peripheral macular thickness (MT) measurements between Stratus optical coherence tomography (OCT) and commercially available Fourier-domain optical coherence tomography (Optovue’s RTvue).
Retrospective chart review of all patients with various pathologies seen between January to July 2007 who had both Stratus and RTvue imaging of the macula on the same day.
Records of 93 eyes from 79 subjects were reviewed. The most common pathology was choroidal neovascular membrane (28%). The mean central MT was 293 +/- 104 µm (range 83 to 757µm) with RTvue-OCT versus 270 +/- 101µm (range 151 to 768 µm) with Stratus-OCT in the central macular region .The mean paired differences +/- standard deviation in macular thickness between RTvue and Stratus in the different ETDRS areas (A1-9) all reached statistical significance (P<0.01) and are as follows: A1--23.2 +/- 36.7 µm, A2--25.4 +/- 28.8µ m, A3--26.9 +/- 30.5 µm, A4--27.6 +/- 44.9 µm), A5--19.7 +/- 32.1 µm, A6--36.4 +/- 33.7 µm, A7--36.7 +/- 32.5µm, A8--27.6 +/- 49.4 µm, and A9--19.6 +/- 32.1 µm. On average RTvue measured higher thickness for all macular areas. Linear regression analysis of the nine different regions of the macula showed the highest tightness of fit (R^2) at the fovea, A1 (0.89) with progressive lower tightness of fit in the peripheral macula.
A statistically significant difference in MT measurement was noted between RTvue and Stratus, in all nine ETDRS areas of the macula. Although a linear correlation was noted between MT measurement obtained with RTvue and Stratus OCT in all nine ETDRS areas, the closest correlation was seen in the central macula with progressively weaker correlation in the peripheral macula.
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