April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Modeling and Analysis of the Hill of Vision of Full-Field Static Perimetry
Author Affiliations & Notes
  • R. Weleber
    Oregon Retinal Degeneration Center, Casey Eye Institute-OHSU, Portland, Oregon
  • P. Francis
    Oregon Retinal Degeneration Center, Casey Eye Institute-OHSU, Portland, Oregon
  • E. Chegarnov
    Oregon Retinal Degeneration Center, Casey Eye Institute-OHSU, Portland, Oregon
  • S. Gardiner
    Discoveries in Sight, Portland, Oregon
  • J. Dietzsch
    Centre for Ophthalmology / Institute for Ophthalmic Research, Univ. of Tuebingen, Tuebingen, Germany
  • U. Schiefer
    Centre for Ophthalmology / Institute for Ophthalmic Research, Univ. of Tuebingen, Tuebingen, Germany
  • C. Johnson
    Department of Ophthalmology, Univ. of Iowa, Iowa City, Iowa
  • Footnotes
    Commercial Relationships  R. Weleber, VFMA, P; Haag-Streit, R; P. Francis, None; E. Chegarnov, None; S. Gardiner, None; J. Dietzsch, Heidelberg Engineering, F; U. Schiefer, Haag Streit, C; C. Johnson, None.
  • Footnotes
    Support  Hear See Hope, Foundation Fighting Blindness, Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3813. doi:
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      R. Weleber, P. Francis, E. Chegarnov, S. Gardiner, J. Dietzsch, U. Schiefer, C. Johnson; Modeling and Analysis of the Hill of Vision of Full-Field Static Perimetry. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3813.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To model the "Hill of Vision" and develop metrics for use in diagnosis, characterization of defects, and as endpoints.

Methods: : We measured differential luminance sensitivity (DLS) values out to 80° temporally with the GATE strategy (Schiefer et al, ARVO 2007 Program #4452), the Octopus 101 perimeter (Haag-Streit, Inc., Koeniz, Switzerland), and radially-oriented, centrally condensed grids of 187, 158, 143, 124, and 102 test locations. We tested 26 normal subjects and 250 patients with one or more grids over the past year. Seven normal subjects (20 to 38 years) were tested with at least two of these grids or static stimuli of both Goldmann size III (26') and size V (103') on a 10 cd/m² background. We modeled the Hill of Vision (HOV) using a flexible spline fit. The volume of the HOV was measured using a newly defined unit, the decibel-steradians (dB-sr). We compared the total volume of the HOV and Mean Sensitivity (MS) among the grids and between the two stimulus sizes.

Results: : The HOV volume and MS did not differ among the grids. DLS values with the 103' stimulus size were 1 to 5 dB greater centrally and 7 to 13 dB greater peripherally than those with the size 26'. Respectively, the mean (±1 SD) MS and HOV volume and ranges were 23.5±0.9 dB and 62.8±4.3 (54.1-70.7) dB-sr for size III (n=31 eyes) and 29.6±1.4 dB and 88.9±5.4 (80.7-99.0) dB-sr for size V (n=30 eyes) stimuli. Test times for the five grids, respectively, averaged 23.1, 20.7, 19.1, 14.6, and 12.0 minutes for normals and from 1 to 6 minutes less for patients. Specific regions of the HOV can be selectively measured as additional endpoints.

Conclusions: : Modeling of the HOV enables 3-D viewing and volumetric measurement of the sensitivity of the entire visual field and provides new insights into the topography of sensitivity in normal subjects and in disease. The size V stimulus provides greater dynamic range for clinical testing. Parameters from HOV modeling provide endpoints for diagnosis and clinical trials.

Keywords: perimetry • visual fields • imaging/image analysis: clinical 
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