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M. Aihara, H. Kurashima, N. Ishida, M. Ichikawa, M. Araie; Effect of Tafluprost on the Intraocular Pressure in Latanoprost Low-Responder Monkeys. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4067.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the effect of tafluprost on intraocular pressure (IOP) in the ocular normotensive monkeys which dose not well respond to latanoprost.
The animals had been trained to IOP measurement before this experiment. IOP was measured using pneumatonometer under conscious. 0.005% latanoprost and saline were topically administrated once a daily (9:00 - 11:00 a.m.) for 7 days. We defined the monkeys which responded 1 mmHg or less IOP reduction as the latanoprost low-responder. 0.0015% tafluprost and saline were topically administrated once a daily (9:00 - 11:00 a.m.) for 7 days to latanoprost low-responder monkeys.
These were 11 latanoprost low-responder monkeys. The baseline IOP before latanoprost administration was 16.6 ± 0.8 mmHg (mean ± S.E.M), and maximal IOP reduction (maximal ΔIOP) was 0.7 ± 0.2 mmHg (Day1) and 0.6 ± 0.1 mmHg (Day7), respectively. Topical administration of tafluprost for 7 days decreased IOP in all latanoprost low-responder monkeys. The baseline IOP before tafluprost administration was 16.5 ± 0.8 mmHg, and maximal ΔIOP was 2.1 ± 0.2 mmHg (Day1) and 2.9 ± 0.2 mmHg (Day7), respectively. The IOP reduction of tafluprost was significant compared with that of saline (Student t-test, p < 0.05).
Topical administration of tafluprost decreased IOP in latanoprost low-responder monkeys. This result suggests that tafluprost may be effective medicine for latanoprost low-responder.
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