April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Effect of Tafluprost on the Intraocular Pressure in Latanoprost Low-Responder Monkeys
Author Affiliations & Notes
  • M. Aihara
    Ophthalmology, Univ of Tokyo School of Medicine, Bunkyo-ku, Japan
  • H. Kurashima
    Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan
  • N. Ishida
    Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan
  • M. Ichikawa
    Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan
  • M. Araie
    Ophthalmology, Univ of Tokyo School of Medicine, Bunkyo-ku, Japan
  • Footnotes
    Commercial Relationships  M. Aihara, None; H. Kurashima, Santen Pharmaceutical Co. Ltd., E; N. Ishida, Santen Pharmaceutical Co. Ltd., E; M. Ichikawa, Santen Pharmaceutical Co. Ltd., E; M. Araie, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 4067. doi:
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    • Get Citation

      M. Aihara, H. Kurashima, N. Ishida, M. Ichikawa, M. Araie; Effect of Tafluprost on the Intraocular Pressure in Latanoprost Low-Responder Monkeys. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4067.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the effect of tafluprost on intraocular pressure (IOP) in the ocular normotensive monkeys which dose not well respond to latanoprost.

Methods: : The animals had been trained to IOP measurement before this experiment. IOP was measured using pneumatonometer under conscious. 0.005% latanoprost and saline were topically administrated once a daily (9:00 - 11:00 a.m.) for 7 days. We defined the monkeys which responded 1 mmHg or less IOP reduction as the latanoprost low-responder. 0.0015% tafluprost and saline were topically administrated once a daily (9:00 - 11:00 a.m.) for 7 days to latanoprost low-responder monkeys.

Results: : These were 11 latanoprost low-responder monkeys. The baseline IOP before latanoprost administration was 16.6 ± 0.8 mmHg (mean ± S.E.M), and maximal IOP reduction (maximal ΔIOP) was 0.7 ± 0.2 mmHg (Day1) and 0.6 ± 0.1 mmHg (Day7), respectively. Topical administration of tafluprost for 7 days decreased IOP in all latanoprost low-responder monkeys. The baseline IOP before tafluprost administration was 16.5 ± 0.8 mmHg, and maximal ΔIOP was 2.1 ± 0.2 mmHg (Day1) and 2.9 ± 0.2 mmHg (Day7), respectively. The IOP reduction of tafluprost was significant compared with that of saline (Student t-test, p < 0.05).

Conclusions: : Topical administration of tafluprost decreased IOP in latanoprost low-responder monkeys. This result suggests that tafluprost may be effective medicine for latanoprost low-responder.

Keywords: intraocular pressure 
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