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U. E. Koskela, S. M. Makela, A. E. Nissinen, M. J. Savolainen, M. J. Liinamaa; High Vitreous Concentrations of Adhesion Molecules and Cytokines in Patiens With Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4982.
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Inflammation may play a prominent role in the pathogenesis of diabetic retinopathy. The objective of the study was to assess vitreous concentrations of adhesion molecules and cytokines in patients with proliferative diabetic retinopathy or maculopathy and non-diabetic controls.
The study population consisted of 46 patients (with type I or type II diabetes) having proliferative retinopathy or maculopathy and 16 non-diabetic subjects who underwent vitreous surgery. The control group had vitrectomy for macular hole or pucker. Undiluted vitreous samples were collected at the beginning of classic three-port pars plana vitrectomy. Vitreous concentrations of 6 adhesion molecules and 11 cytokines were detected by the flowcytometry based Multiplex assay.
The mean diabetes duration was 22.9 years. The vitreous concentrations of IL-6, IL-8, IL-10 and sPECAM-1, sE-selectin, sICAM-1 and sVCAM-1 were significantly higher in patients with diabetic retinopathy than control subjects.
In conclusion, high concentrations of vitreous cytokines and adhesion molecules suggest that adhesion molecules and inflammation are involved with the development of diabetic retinopathy.
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