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S. Kubota, T. Kurihara, K. Noda, Y. Ozawa, Y. Oike, S. Ishida, K. Tsubota; Resveratrol Suppresses Ocular Inflammation in the Diabetic Retina. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4986.
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Resveratrol is known as one of the dietary polyphenols found in red wine and grape skin. It has been reported that resveratrol prevents tumorigenesis and aging; however, the effect of resveratrol on ocular pathology still remains unclear. In this study, we investigated the anti-inflammatory role of resveratrol in the diabetic retina.
C57BL/6 mice with streptozotocin-induced diabetes were orally treated with resveratrol at the dose of 50mg/kg for seven days. Leukocyte adhesion to the retinal vasculature was evaluated with the concanavalin A lectin perfusion-labeling technique. Retinal protein levels of intercellular adhesion molecule (ICAM)-1 and VEGF were examined by ELISA.
Administration of resveratrol significantly (P < 0.01) reduced leukocyte adhesion to the retinal vessels of diabetic mice by 40%. In addition, the diabetic animals treated with resveratrol showed a significant (P < 0.01) decrease in retinal ICAM-1and VEGF, which were upregulated following the induction of diabetes.
Resveratrol suppressed leukocyte adhesion together with the inflammatory molecules in the diabetic model. The current data suggest the potential use of resveratrol as a therapeutic agent for diabetic retinopathy.
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