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K. H. Baratz, R. C. Young, D. O. Hodge, T. J. Liesegang; Incidence of Herpes Simplex Eye Disease in Olmsted County, Minnesota, 1976 - 2007. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5044.
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To determine trends in the incidence of eye disease due to Herpes Simplex virus (HSV) in a geographically-defined population during a 32 year period.
Potential incident cases of ocular HSV were identified by using the databases of the Rochester Epidemiology Project (REP), a medical record linkage system designed to study medical care in Olmsted County, Minnesota. Databases were searched for any diagnostic code related to HSV eye disease, excluding blepharitis or conjunctivitis, between January 1, 1976 and December 31, 2007. Medical records of incident cases were manually reviewed to confirm diagnoses and to identify initial disease episodes. Olmsted County residency status was confirmed by using a combination of automated and manual methods. Incidence rates were calculated based on US census data with linear interpolation for intervening years for which data were not available. Rates were age- and sex-adjusted to census data for the 2000 US white population. Trends were evaluated by using the Poisson regression model.
A total of 283 incident cases were identified, of which 140 (49%) were female. No incident cases had posterior segment disease. The age- and sex- adjusted incidence of ocular HSV during the entire study period was 8.9 (95% C.I.: 7.8 - 9.9) per 100,000 population per year. Annual rates per 100,000 among men [9.9 (8.2 to 10.6)] and women [8.1 (6.7 to 9.5)] were similar (p=0.18). The annual incidence per 100,000 population increased with age, from 2.4 (1.3 to 4.1) during the first decade of life to 23.7 (15.2 to 35.3) after the ninth decade (p<0.001). There was no identifiable trend in the age- and sex- adjusted incidence per 100,000 over the 32 year period. The annual rate of new cases per 100,000 population was 8.1 (5.8 to 10.4) during the first 8 years and 10.4 (8.3 - 12.5) during the final 8 years (p=0.46).
The incidence of an initial episode of ocular HSV increases with advancing age. No trend over a 32 year study period or difference among genders was identified. Generalizing these data to the 2000 US white population, we would predict 18,800 (16,500-20,900) new cases annually in the US.
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