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Y. Morimoto, N. Maeda, R. Higashiura, T. Nakagawa, M. Shimabukuro, Y. Hori, T. Inoue, Y. Tano; The Inter-Eye Asymmetry in Anterior Surface, Posterior Surface, and Thickness of Cornea in Patients With Keratoconus and Keratoconus Suspect. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5079.
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To examine the relationship between-eye asymmetry and severity of disease in patients with keratoconus and keratoconus suspect.
The subjects were divided into three groups based on the severity of the worse eye: keratoconus (KC) group with 32 eyes of 16 patients, keratoconus suspect (KCS) group with 46 eyes of 23 patients and normal group with 30 eyes of 15 subjects. Corneal topography was determined by a rotating Scheimpflug camera (Pentacam HR: Oculus, Wetzlar, Germany) for both eyes, and differences between eyes for the following parameters were compared among three groups; minimal corneal thickness (Tmin), thickness at the apex (Tapex), anterior chamber depth (ACD), anterior elevation (Eant), posterior elevation (Epost), anterior corneal power at center (Pant), and posterior corneal power at center (Ppost).
Differences in Tmin between eyes (34.7 ± 48.2 for KC, 7.7 ± 5.7 for KCS, 10.5 ± 10.2 µm for normal) and Tapex (26.3 ± 46.0, 8.4 ± 6.5, 11.3 ± 10.8 µm) were significant in all three groups (p <0.05). Between-eye differences of ACD,Epost, and Ppost were significant only in the KC group (p <0.05). Although differences for all parameters except Tapex were significant between KC group and KCS group and between KC group and normal group, there were no significant differences between both eyes for all indices between KCS group and normal group.
Asymmetry between eyes is greater in keratoconus with more severe disease. The inter-eye asymmetry was more prominent for the corneal thickness followed by posterior corneal surface, ACD, and anterior corneal surface.
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