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J. Merayo-Lloves, T. Blanco, J. Hincapie, R. Cantalapiedra, P. Perez-Merino, I. Alcalde, P. Gallego, S. del Olmo-Aguado, L. Ibares-Frias, S. Mar; Long-term Light Scattering Measurements After Corneal Collagen Cross-Linking Using Riboflavin/UVA Treatment (CXL). Invest. Ophthalmol. Vis. Sci. 2009;50(13):5460.
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To evaluate the long-term effect of combined riboflavin-ultraviolet A (UVA) treatment (CXL) in the forward light scattering of the hen cornea.
The corneas of the right eyes of eight Lohmann Classic hens were crosslinked by application of the photosensitizer riboflavin and exposure to UVA light (370 nm, 3 mW/cm2) for 30 minutes. The left fellow control eyes were deepithelialized. Direct transmittance and corneal light scattering were measured at 6 and 10 months using a scatterometer developed by our group. Differences between the crosslinked and deepithelializated eyes were compared with untreated control eyes. All eyes were fixed for histological analysis.
There was a significant decrease in forward light scattering after cross-linking over a time period of 6 to 10 months compared with the deepithelialization and the control groups.
Riboflavin/UVA-induced collagen cross-linking leads to a long-term decrease in forward light scattering in the hen corneas which remains stable over time.
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