April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Aberrations of the Cornea Following Collagen Cross-Linking for Keratoconus
Author Affiliations & Notes
  • M. Baumeister
    Ophthalmology, Goethe University, Frankfurt am Main, Germany
  • O. K. Klaproth
    Ophthalmology, Goethe University, Frankfurt am Main, Germany
  • J. Buehren
    Ophthalmology, Goethe University, Frankfurt am Main, Germany
  • T. Kohnen
    Ophthalmology, Goethe University, Frankfurt am Main, Germany
  • Footnotes
    Commercial Relationships  M. Baumeister, None; O.K. Klaproth, None; J. Buehren, None; T. Kohnen, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5488. doi:
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      M. Baumeister, O. K. Klaproth, J. Buehren, T. Kohnen; Aberrations of the Cornea Following Collagen Cross-Linking for Keratoconus. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5488.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Collagen cross-linking with application of riboflavin and UV radiation may delay or halt the progression of keratoconus. This study examines the effects of the treatment on the corneal wavefront error.

Methods: : Twenty eyes of 20 patients with Keratoconus received collagen cross-linking with riboflavin application and 30 min of UV radiation with a wavelength of 370 nm. Preoperatively and 1 and 6 months postoperatively, the corneal wavefront error was computed from axial keratometric topography data by Zernike decomposition over a pupil diameter of 6 mm.

Results: : Preoperative mean keratometric astigmatism was 5.37 +/- 2.36 D. Six months posoperatively it was 5.29 +/- 2.73 D (p=0.35). Total higher order aberrations were preoperatively 3.35 +/- 1.65 µm and after 6 months 3.31 +/- 1.79 µm (p= 0.116). Coma root mean square was 2.94 +/- 1.47 µm preoperatively and 2.75 +/- 1.38 µm after 6 months (p=0.047). The logarithm of the visual Strehl ratio of the optical transfer function with best sphero-cylindrical correction (BCVSOTF) was -1.50 +/- 0.26 before the procedure and -1.44 +/- 0.31 after 6 months (p=0.40).

Conclusions: : Within the first 6 postoperative months, collagen cross-linking with riboflavin application and UVA irradiation does not significantly increase or decrease corneal wavefront aberrations.

Keywords: cornea: clinical science • aberrations • topography 
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