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M. L. Heynen, H. Lorentz, K. Dumbleton, J. Varikooty, C. Woods, L. W. Jones; Lipid Deposition on Senofilcon A Silicone Hydrogel Contact Lenses Disinfected with 1-Step Hydrogen Peroxide and Polyquad®/Aldox®-Preserved Care Regimens. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5660.
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To determine the degree of lipid deposition associated with senofilcon A silicone hydrogel lenses (J&J Acuvue OASYS) when disinfected with a no-rub 1-step hydrogen peroxide system (CIBA Vision ClearCare) or a Polyquad®/Aldox®-preserved (5 second rinse) system (Alcon OPTI-FREE RepleniSH).
30 existing soft lens wearers symptomatic of dryness were enrolled into this four-week prospective, randomized, bilateral eye (lens type), cross-over (care regimen), daily wear, masked study. Subjects were refitted with senofilcon A lenses, which were replaced biweekly. During each period of wear, subjects used either the peroxide or Polyquad®/Aldox®-based systems. After each period of wear, lenses were collected aseptically and lipid was extracted using 1.5 ml of a 2:1 chloroform:methanol solution for 3 hours. Lens extracts were analyzed for lipids using normal phase HPLC.
The lipids that were specifically investigated were cholesterol oleate, cholesterol, oleic acid, triolein and oleic acid methyl ester. The predominant lipids detected were cholesterol oleate and cholesterol. Oleic acid and triolein contributed less than 1% of the total lipid and no oleic acid methyl ester was found on any of the lenses. The total lipid detected for each care regimen was 34 ± 28 µg/lens for ClearCare and 22 ± 21 µg/lens for OPTI-FREE RepleniSH (p=0.029). While there was no difference between products for cholesterol (1.4 vs 1.3 µg/lens; p=0.50), use of OPTI-FREE RepleniSH resulted in significantly less deposited cholesterol oleate (33 ± 28 vs 21 ± 20 µg/lens; p=0.033).
In symptomatic soft lens wearers using biweekly replaced senofilcon A lenses disinfected with a no-rub 1-step peroxide system or a rinse-step Polyquad®/Aldox®-based system, approximately 95% of the detectable lipid deposited on the materials was cholesterol oleate. The lenses disinfected with the Polyquad®/Aldox®-based system deposited 36% less total lipid than lenses disinfected with the peroxide-based system.
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