Purchase this article with an account.
M. A. Blasi, G. Savino, L. Balia, D. Colucci, M. G. Sammarco, E. Colangelo, C. G. Caputo, E. Balestrazzi; A New Diagnostic Approach to Orbital Lymphoproliferative Disease. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5729.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To describe the Fine needle Aspiration Cytology (FNAC) associated to Thin Prep (TP) technique as a new approach to Orbital Lymphoproliferative Disease (OLD).
Fifteen patients with clinical and radiological suspicion of OLD underwent FNAC. The cellular material was processed with both traditional and Thin Prep2000TM methods (Cytyc Co., Marlborough, MA, U.S.A.) and stained with Papanicolaou stain. Immunohistochemical (IHC). Molecular investigations were carried out on the thin-layer slides when needed. All patients had subsequent incisional biopsies to confirm the cytological results.
The series included: 7 reactive lymphoid hyperplasias, 4 MALT (Mucosa Associated Lymphoid Tissue) lymphomas, 2 diffuse large B-cell lymphomas, 1 lymphoplasmacytic lymphoma, 1 follicular lymphoma. All cases diagnosed on preliminary FNAC evaluation were confirmed by final histopathological interpretation (15/15).
TP technique should be considered as a new valid diagnostic approach to OLD that improves the diagnostic accuracy of orbital FNAC allowing determination of lesion subtype and selection of appropriate therapy.
This PDF is available to Subscribers Only