Purchase this article with an account.
P. L. Ballalai, J. Ribeiro, V. L. L. Torres, M. C. Martins; Local Recurrences and Sistemic Metastasis in Patients With Conjunctival Malignant Melanoma in a Referral Service in Brazil. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5734.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Twenty eyes of 19 patients were included. The mean follow up of the group was 28,3months (2-108mo). The tumor was more frequent in caucasians (63,2%) and women (57,9%). The average age was of 56,8years old (29-87yo). The disease was unilateral in 18 (94,7%) patients, and one patient (5,3%) had lesions in both eyes. The perilimbal conjunctiva was the most frequent location (55%), and the majority of the lesions were solitary (75%) and pigmented (90%). Association with PAM and nevus was identified in 55% of the cases: nevus in 6 eyes (30%) and PAM in 5 eyes (25%). In 8 eyes (40%) the pathology was inconclusive. Multifocal disease occurred in 25% of the cases and was related with PAM in most cases (p=0,005). All patients were submitted to primary surgery: local excision in 19 eyes and exenteration in one eye, due to advanced disease. Adjuvant treatment with cryotherapy and/or topical MMC 0,02% post operatively was used in 50% of the cases. MMC 0,02% was used after two weeks of the surgery for 14 days. During the follow up, 5 eyes (25%) had local recurrence. Despite of the treatment, 3 of these eyes presented with more than one local recurrence. Metastasis occurred in 3 (15,5%) patients: 2 cases to local lymph nodes and 1 to the eyelid. Two of these patients had previous local recurrence, but this was not statistically significant. Statistical analysis showed that the use of adjuvant treatment at the first approach did not reduce the risk of local recurrences (p=0,141) but seems to reduce the risk of metastasis (p=0,087).
Clinical Trial: :
This PDF is available to Subscribers Only