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Y. Chung, J. Choi, S. Ko, J. Lee; Standard Automated Static Perimetry in Patients With Pituitary Macroadenoma: Correlation With Tumor Size. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5740.
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To evaluate the relationship between the tumor size and the severity of visual field defects and classify the unusual scotoma in patients with pituitary macroadenoma using Humphrey field analyzerMethods and Subjects: Thirty-nine patients with pituitary macroadenoma judged by brain MRI preoperatively underwent Humphrey field analyzer (SITA - standard C30-2 or C24-2 algorithms) twice. First, the patients were differentiated into 2 groups by the existence of visual field defect and calibrated the size of the tumor. Second, to further elaborate statistical data we assessed the correlations between the tumor volume and mean deviation (MD), pattern standard deviation (PSD), and the number of defective quadrants, respectively. Last, the patterns of atypical scotoma were classified.
The tumor volume of patients with visual field defect (29 patients, 10.57 ± 6.85 cm3) was larger than ones without visual field defect (10 patients, 3.32 ± 2.29 cm3) (P = 0.006). Moreover, the tumor volume was significantly correlated with MD (r = - 0.779, P = 0.000), PSD (r = 0.666, P = 0.000) and the number of defective scotoma (r = 0.672, P = 0.000). Finally uniocular temporal defects were observed in 7 patients (18%) and homonymous hemianopsia in 3 patients (8%), both without obvious bitemporal hemianopsia.
Through the Humphrey visual field exams of patients with pituitary macroadenoma, the study concluded that the tumor size is well-correlated with the severity of visual field defects. Also, when analyzing the patients it must be taken into consideration that atypical field defects without bitemporality maybe presented.
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