April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Factors Correlating With Rnfl Measurements by Gdx-vcc & Ecc Algorithms in Normal Subjects
Author Affiliations & Notes
  • A. Iwase
    Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
  • M. Araie
    Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
  • R. Gurses-Ozden
    Carl Zeiss Meditec, Inc.,, Dublin, California
  • K. A. Soules
    Carl Zeiss Meditec, Inc.,, Dublin, California
  • Q. Zhou
    Carl Zeiss Meditec, Inc.,, Dublin, California
  • V. Atkinson
    Carl Zeiss Meditec, Inc.,, Dublin, California
  • Y.-J. Duh
    ClinReg Consulting Services, Newport Beach, California
  • GDx ECC Normative Database Study Group
    Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
  • Footnotes
    Commercial Relationships  A. Iwase, Carl Zeiss Meditec, F; M. Araie, None; R. Gurses-Ozden, Carl Zeiss Meditec, E; K.A. Soules, Carl Zeiss Meditec, E; Q. Zhou, Carl Zeiss Meditec, E; V. Atkinson, Carl Zeiss Meditec, E; Y.-J. Duh, Carl Zeiss Meditec, E.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5821. doi:
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      A. Iwase, M. Araie, R. Gurses-Ozden, K. A. Soules, Q. Zhou, V. Atkinson, Y.-J. Duh, GDx ECC Normative Database Study Group; Factors Correlating With Rnfl Measurements by Gdx-vcc & Ecc Algorithms in Normal Subjects. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5821.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the effects of ethnicity, age, gender, axial length (AL), central corneal thickness (CCT), IOP, vertical Cup/Disc ratio (v-C/D) and presence of peripapillary atrophy (PPA) on the retinal nerve fiber layer (RNFL) measurements by GDx-Variable Corneal Compensator algorithm (VCC) and Enhanced Corneal Compensator algorithm (ECC) obtained in normal subjects.

Methods: : Normal subjects were enrolled in 10 international sites and underwent comprehensive ophthalmologic examinations and 3 GDx-VCC and ECC measurements. RNFL measurements were correlated with race, age, gender, AL,IOP,CCT, v-C/D and presence of PPA by multivariate regression analysis.

Results: : Data from 249 normal eyes (249 subjects from various races with median age of 47 (18 - 82) yrs. old) were analyzed. TSNIT avg. averaged 54.2 ± 4.7 for VCC and 52.6 ± 4.6 µm for ECC (P<0.001). Asians gave significantly thicker value for TNSIT, Superior, Inferior avg. and Temporal median by ECC and Inferior avg. by VCC (P=0.041-<0.001). Age showed small, but significant negative correlation with TNSIT and Superior avg. by VCC and ECC, Inferior avg. by ECC (Partial correlation coefficient, PC= -0.16 - -0.26, P=0.014 - <0.001) and positive correlation with Temporal median by VCC (PC=0.22, P=0.003) ; AL showed small, but significant positive correlation with TSNIT and Superior avg. by VCC, Superior avg. by ECC and Temporal median by VCC (PC= 0.14 - 0.20, P=0.020 - 0.003); v-C/D showed small, but significant negative correlation with TSNIT avg. by ECC and VCC (PC= -0.14, -0.16, P=0.029, 0.014); and PPA influenced only Temporal median by VCC (P=0.022).

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic disc • nerve fiber layer 
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