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L. J. McCranor, A. Harris, B. Siesky, A. Moss, L. Cantor, J. Abrams, D. WuDunn, M. Pickett, R. Ehrlich; Retinal Capillary Blood Flow Correlates With Central Retinal Artery Vascular Resistance in Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5871.
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To compare retinal capillary blood flow with ophthalmic and central retinal artery blood flow and vascular resistance in primary open angle glaucoma (OAG) patients participating in the Indianapolis Glaucoma Progression Study (IGPS).
An analysis of 40 patients with OAG (mean age 62.9 (10.2); 18 female) participating in the IGPS was performed to compare retinal capillary blood flow with the blood vessels supplying these tissues. Retinal capillary blood flow was assessed using Heidelberg retinal flowmetry (HRF) imaging and the pixel-by-pixel analysis method to determine mean retinal capillary blood flow and the percentage of pixels with zero blood flow (representing no capillary blood flow). Immediately following HRF, color Doppler imaging (CDI) of the ophthalmic (OA) and central retinal arteries (CRA) was performed. The peak systolic velocity (PSV), end diastolic velocity (EDV) and Pourcelot’s vascular resistance (RI) of each vessel were assessed. Correlations between HRF and CDI parameters were determined by linear regression. Pearson correlation coefficients were utilized to assess the strength of the associations. P values <0.05 were considered statistically significant.
In the CRA, a decrease in the RI significantly correlated with an increase in the percentage of zero-flow pixels (r=-0.20; p=0.037). The RI of the OA was not significantly correlated with the percentage of zero-flow pixels (r=0.0; p=0.5). Mean retinal capillary flow was not significantly correlated with the hemodynamics of either vessel. PSV and EDV of the OA and CRA were not significantly correlated with mean retinal capillary flow or the percentage of zero blood flow pixels.
This data suggests that the vascular resistance of the CRA decreases in response to lower retinal capillary blood flow of OAG patients. Conversely, vascular resistance of the OA is apparently not affected by changes in retinal capillary circulation in OAG patients.
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