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R. Wong, C. Pavesio, T. H. Williamson, D. A. H. Laidlaw, E. Graham, M. R. Stanford; Varicella Zoster vs. Herpes Simplex: Predicting Visual Outcome in Acute Retinal Necrosis. Invest. Ophthalmol. Vis. Sci. 2009;50(13):6188.
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To analyze the clinical differences between varicella zoster (VZV-ARN) and herpes simplex (HSV-ARN) induced acute retinal necrosis
33 eyes had HSV-ARN and 48 had VZV-ARN. Average age for HSV-ARN was 33 and 48 for VZV-ARN (p=0.00054). VA on presentation was found to be similar (p=0.48), but a larger proportion had better vision (≥20/60) in the HSV-ARN group (52%) than the VZV-ARN group (42%). Final VA: greater proportion of eyes with poor vision (≤20/200) in the VZV-ARN group (60%) compared to the HSV-ARN group (35%). A statistically significant (p=0.016) greater degree of visual loss in the VZV-ARN group (0.4 logMAR) compared to the HSV-ARN group (0.04 logMAR) was detected. Retinal detachment was 2.5 fold more common in VZV-ARN (62%) compared to HSV-ARN (24%).
The results support the difference of outcome in HSV-ARN and VZV-ARN. Therefore, viral identification serves as a key to predicting outcome in these patients.
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