May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Functional Assessment in Glaucoma Suspect and Glaucomatous Eyes: A Comparison of mfVEP, FDT and SWAP
Author Affiliations & Notes
  • F. N. Kanadani
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • V. C. Greenstein
    Ophthalmology,
    Columbia University, New York, New York
  • T. M. Grippo
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    Medicine, Beth Israel Medical Center, New York, New York
  • B. Wangsupadilok
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • J. M. Liebmann
    Ophthalmology, Manhattan Eye, Ear & Throat Hospital, New York, New York
  • R. Ritch
    Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • D. C. Hood
    Psychology,
    Columbia University, New York, New York
  • Footnotes
    Commercial Relationships F.N. Kanadani, None; V.C. Greenstein, None; T.M. Grippo, None; B. Wangsupadilok, None; J.M. Liebmann, None; R. Ritch, None; D.C. Hood, None.
  • Footnotes
    Support NIH/NEI grant EY02115
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 218. doi:
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    • Get Citation

      F. N. Kanadani, V. C. Greenstein, T. M. Grippo, B. Wangsupadilok, J. M. Liebmann, R. Ritch, D. C. Hood; Functional Assessment in Glaucoma Suspect and Glaucomatous Eyes: A Comparison of mfVEP, FDT and SWAP. Invest. Ophthalmol. Vis. Sci. 2007;48(13):218.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To compare subjective and objective tests of visual function at different stages of glaucoma.

Methods:: Seventy-two subjects enrolled in a prospective study were evaluated with frequency doubling technology perimetry (FDT), short-wavelength automated perimetry (SWAP), and the multifocal visual evoked potential (mfVEP) technique. The subjects were placed in the following groups based upon the results of standard achromatic perimetry (SAP): 22 eyes were classified as glaucoma suspect (GS) (normal glaucoma hemifield test (GHT) and mean deviation (MD)), 21 eyes as early glaucoma (MD < -6 dB), and 13 as moderate glaucoma (MD > -6 dB). Eyes with early or moderate glaucoma had glaucomatous optic neuropathy and abnormal GHTs and MDs on SAP. FDT was performed with the Humphrey Matrix (24-2 program), SAP with the Humphrey Field Analyzer II (24-2 program), and mfVEPs with the VERIS system using a 60 sector pattern-reversal dartboard array. SWAP and FDT fields were classified as abnormal when the GHT was outside normal limits and there were 3 or more contiguous points in an hemifield of the pattern deviation plot with p<0.05. The mfVEP was considered abnormal when the interocular or monocular probability plot had 3 or more contiguous points in a hemifield with p<0.05 and at least one of these points had p<0.01.

Results:: In the GS group, SWAP, FDT and mfVEP tests revealed visual field abnormalities in 18%, 36% and 59% of eyes, respectively. In early glaucoma, abnormalities were noted in 70% (SWAP), 81% (FDT) and 67% (mfVEP). In moderate glaucoma, abnormalities were noted in 100% (SWAP), 100% (FDT) and 92% (mfVEP). The specificity was greater in SWAP (89%) than in FDT (75%) and mfVEP (80%).

Conclusions:: In view of the differences in detection of functional deficits between the subjective and objective tests, we suggest that a combination of one subjective (FDT or SWAP) and one objective (mfVEP) test be used for follow-up and early detection of glaucoma.

Keywords: electrophysiology: clinical • visual fields • perimetry 
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