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N. Yasuda, H. Kawamura, O. Sawada, M. Ohji; Intraocular Cytokines in the Treatment of Intraocular Lymphoma by Intravitreal Injection of Methotrexate. Invest. Ophthalmol. Vis. Sci. 2007;48(13):253.
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To evaluate the effectiveness of measuring anterior chamber interleukin-10 (IL-10) and IL-6 concentrations in the treatment of intraocular lymphoma by intravitreal injection of methotrexate.
Two patients (3 eyes) underwent repeated weekly intravitreal injections of methotrexate for 6 weeks. We monitored the anterior chamber IL-10 and IL-6 concentrations and the IL-10/IL-6 ratio at baseline and at the last injections. IL-10 and IL-6 were determined using a standard enzyme-linked immunoassay.
Repeated intravitreal injections of methotrexate reduced vitreous opacity. The IL-10/IL-6 ratio consistently decreased in conjunction with clearance of vitreous opacity in 3 eyes; from 39.2 to 0.02, 1.67 to 0.03 and 3.05 to 0.159, respectively.
A decrease in the IL-10/IL-6 ratio seems to be related to decreased vitreous opacity. Measuring the IL-10/IL-6 ratio in the anterior chamber may be useful to evaluate the effect of treatment of intraocular lymphoma.
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