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C. Rosina, F. Viola, P. Avanza, G. Staurenghi; Efficacy of Intravitreal Bevacizumab in Patients With Choroidal Neovascularization (CNV) in Angiod Streaks. Invest. Ophthalmol. Vis. Sci. 2007;48(13):279.
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To evaluate the efficacy of intravitreal Bevacizumab in the treatment of CNV in patients with angioid streaks, unresponsives to photodynamic or laser therapy
Retrospective chart review of 10 eyes treated with intravitreal (IVT) Bevacizumab (1.25mg) for CNV secondary to angioid streaks. The diagnosis of CNV was confirmed by fluorescein and indocyanine green angiography. Outcome measures included visual acuity (VA), retinal thickness with OCT, and degree of leakage on fluorescein and indocyanine green angiography.
At 1 month post injection in 5 of 10 (50%) eyes the fluorescein and indocyanine green angiography (FAG+ICGA) demonstrated decreased hyperfluorescence, the VA was stable and the OCT showed a decrease of retinal thickness, in 1 of 10 (10%) eyes decreased hyperfluorescence in angiogragraphy, decreased retinal thickness with OCT with decrease of VA, in 2 of 10 (20%) eyes VA, FAG+ICGA and OCT were stable with decreased metamorphopsia and in 2 of 10 (20%) eyes FAG+ICGA, OCT and VA were stable. At 3 months post injection VA, FAG+ICGA, OCT were stable in 10 of 10 (100%) eyes. At 6 months post injection we have the follow up of 7 eyes: in 5 of 7 (71,4%) eyes FAG+ ICGA, OCT and VA were stable, in 1(14,3%) eye FAG+ICGA demonstrated increased hyperfluorescence, OCT showed increased retinal thickness while the vision was stable, 1 (14,3%) patient presented metamorphopsia with FAG+ICGA, OCT and VA stable. After 6 months 2 of 7 (28,6%) eyes had a second IVT of bevacizumab. At 8 months post injection we have the follow up of 5 eyes: 2 of 5 (40%) eyes were stable, in 2 of 5 (40%) eyes the VA was stable but the FAG+ICGA demonstrated decreased hyperfluorescence and the OCT showed increased retinal thickness, in 1 of 5 (20%) eyes appeared metamorphopsia with vision, FAG+OCT and OCT stable. 3 eyes had a second injection of bevacizumab. At 1 year post injection we have the follow up of 1 eye: VA, angiography and OCT were stable.
After 6 months in CNV angioid streaks Intravitreal Bevacizumab showed a good efficacy, in particular considering the effect of other previous treatments. Further clinical trials are needful to evaluate a longer follow-up.
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