May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Focal Macular Electroretinogram of Cynomolgus Monkey (Macaca fascicularis) With Early Onset Macular Degeneration
Author Affiliations & Notes
  • T. Yoshida
    National Institute of Sensory Organs, Tokyo Medical Center/NHO, Tokyo, Japan
  • K. Fujinami
    National Institute of Sensory Organs, Tokyo Medical Center/NHO, Tokyo, Japan
  • K. Shinoda
    National Institute of Sensory Organs, Tokyo Medical Center/NHO, Tokyo, Japan
  • Y. Miyake
    National Institute of Sensory Organs, Tokyo Medical Center/NHO, Tokyo, Japan
  • M. T. Suzuki
    The Corporation for Production and Research of Laboratory Primates, Tsukuba, Japan
  • K. Terao
    Tsukuba Primate Reseach Center, National Institute of Biomedical Innovation, Tsukuba, Japan
  • Y. Yoshikawa
    Department of Biomedical Science, Graduate school of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
  • T. Iwata
    National Institute of Sensory Organs, Tokyo Medical Center/NHO, Tokyo, Japan
  • Footnotes
    Commercial Relationships T. Yoshida, None; K. Fujinami, None; K. Shinoda, None; Y. Miyake, None; M.T. Suzuki, None; K. Terao, None; Y. Yoshikawa, None; T. Iwata, None.
  • Footnotes
    Support Ministry of Health, Labour and Welfare of Japan
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 35. doi:
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    • Get Citation

      T. Yoshida, K. Fujinami, K. Shinoda, Y. Miyake, M. T. Suzuki, K. Terao, Y. Yoshikawa, T. Iwata; Focal Macular Electroretinogram of Cynomolgus Monkey (Macaca fascicularis) With Early Onset Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):35.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To evaluate sensory retinal function of macula by focal macular electroretinogram on Cynomolgus monkey (Macaca fascicularis) pedigree with early onset macular degeneration.

Methods:: The clinical fundus findings of pedigree with early onset macular degeneration (58 monkeys) were classified to 4 disease stage. Furthermore, the progression of the disease was confirmed based on previous records. To evaluate sensory retinal function of macula, focal macula electroretinograms(ERGs)was measured at 5, 10, and 15 degree angles around fovea for two individual monkeys at each stage of 0 to 3 under the fundus monitor during the recording.

Results:: Only few cases were traced back to over 7 years. However, significant deterioration of fundus within one year period was confirmed in 7 monkeys. In several monkeys drastic deterioration of fundus during 2 to 5 years after birth leading to dry-type AMD were observed. In these monkeys focal macula ERGs demonstrated the amplitudes around fovea were reduced and the oscillatory potentials were occasionally absent. Difference in amplitudes of focal macula ERGs between stage 3 monkeys and others became smaller as stimuli range was widen. These results suggest the accumulation of drusen tends to damage around fovea but not peripheral.

Conclusions:: Focal macula ERGs was measured for Cynomolgus monkey pedigree with early onset macular degeneration. Affected monkeys showed deterioration of fundus findings by age in most cases. Deterioration of fundus findings of this monkey pedigree caused functional disorder of sensory retina specifically around fovea. These observations are similar to that of dry-type human AMD. This AMD monkey pedigree is potentially useful as animal model for AMD to test new therapies including anti- complement system drugs.

Keywords: age-related macular degeneration • drusen • electroretinography: non-clinical 
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