May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Determination of the Most Effective Tests in Differentiating Chronic Blepharitis From Dry Eye
Author Affiliations & Notes
  • A. Tomlinson
    Glasgow Caledonian University, Glasgow, United Kingdom
    Department of Vision Sciences,
  • S. Khanal
    Glasgow Caledonian University, Glasgow, United Kingdom
    Department of Vision Sciences,
  • A. McFadyen
    Glasgow Caledonian University, Glasgow, United Kingdom
    Department of Computing and Mathematical Science,
  • C. Diaper
    Southern General Hospital, South Glasgow University Hospital Trust, Glasgow, United Kingdom
  • K. Ramaesh
    Gartnavel Hospital, North Glasgow Hospital University Trust, Glasgow, United Kingdom
  • Footnotes
    Commercial Relationships A. Tomlinson, None; S. Khanal, None; A. McFadyen, None; C. Diaper, None; K. Ramaesh, None.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 412. doi:
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      A. Tomlinson, S. Khanal, A. McFadyen, C. Diaper, K. Ramaesh; Determination of the Most Effective Tests in Differentiating Chronic Blepharitis From Dry Eye. Invest. Ophthalmol. Vis. Sci. 2007;48(13):412.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To determine the differences in tear physiology of patients with chronic blepharitis and dry eye and identify the most effective battery of tests in the differential diagnosis of these two conditions.

Methods:: Two groups of subjects, 19 patients with chronic blepharitis and 41 with dry eye had a range of tear physiology measures assessed which included tear turnover, evaporation, structure, volume and osmolarity and meibomian gland dysfunction (MGD).

Results:: No significant differences or distinct cut-offs were seen in tear turnover rate, evaporation, structure, volume and osmolarity between patients with chronic blepharitis and dry eye. MGD score (with a cut-off value of 2 dysfunctioning glands) was found to be useful to differentiate blepharitis from dry eye with sensitivity of 79%, specificity 69%, positive predictive value of 60%, negative predictive value of 85% and overall accuracy of 62%. Series and parallel combinations of tests were not found to be more effective in the differential diagnosis of these conditions. Discriminant function analysis was also applied but it removed all the parameters, except MGD scores, from the discriminant function.

Conclusions:: There are limited differences in tear physiology in patients with chronic blepharitis and dry eye. Meibomian gland dysfunction is the most effective measure in differentiating between these two conditions.

Keywords: cornea: tears/tear film/dry eye 
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