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J. Wang, J. R. Palakuru, J. V. Aquavella; Correlations Among Tear Menisci, Non-Invasive Tear Break-Up Time and Schirmer’s Test. Invest. Ophthalmol. Vis. Sci. 2007;48(13):426.
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The aim was to determine correlations among upper and lower tear menisci, non-invasive tear break-up time and Schirmer’s test in normal people.
Thirty-six healthy subjects (16 men and 20 women, mean ± SD age: 45 ± 15 years, ranged from 20 to 70 years) without previously diagnosed dry eye were recruited. A real-time corneal optical coherence tomography (OCT) was used to image upper and lower tear menisci immediately after blinks during normal and delayed blinking sessions. A video monitoring Keeler Tearscope was used to measure non-invasive tear break-up time (NITBUT). A routine Schirmer’s test with topical anaesthetic was also performed. One randomly selected eye of each subject was studied to avoid possible sympathetic reaction between eyes.
Compared to normal blinking, significant increases of the radius, height and cross-sectional area of upper and lower tear menisci were found during delayed blinking session when the subject was asked to hold the eye open as long as she/he could (ANOVA, P < 0.01, post hoc test, p < 0.01). NITBUT was significantly related to the height (r = 0.36, P = 0.03) and area (r = 0.37, P = 0.03) of lower tear meniscus measured during normal blinks. Schirmer’s test was significantly related to the age (r = -0.47, P = 0.004). The age also was significantly and negatively related to upper tear meniscus (r ranged from 0.36 to 0.37 for the radius, height and area, P < 0.05) measured during delayed blinking session.
NITBUT appears to relate to lower tear meniscus measured at baseline and the invasive Schirmer’s test may not relate to both tear menisci measured non-invasively. This study was supported by research grants from NEI (R03 EY016420), Bausch & Lomb, Allergan and the Challenging grant from Research to Prevent Blindness (RPB).
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