May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Correlations Between Neuroretinal Rim and Nerve Fiber Layer With Visual Function Tests in Advanced Glaucoma Patients
Author Affiliations & Notes
  • J. S. Parker, Jr.
    Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama
  • J. E. De Leon-Ortega
    Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama
  • C. A. Girkin
    Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama
  • Footnotes
    Commercial Relationships J.S. Parker, None; J.E. De Leon-Ortega, None; C.A. Girkin, None.
  • Footnotes
    Support NIH Grant EY 14267-05 and grant support from the UAB Dept. Ophthalmology
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 486. doi:
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      J. S. Parker, Jr., J. E. De Leon-Ortega, C. A. Girkin; Correlations Between Neuroretinal Rim and Nerve Fiber Layer With Visual Function Tests in Advanced Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2007;48(13):486.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine the linear structure-function relationship between neuroretinal rim and retinal nerve fiber layer with peripheral and central field functional tests in glaucoma patients with advanced field loss and with relative good central visual acuity.

 
Methods:
 

41 patients with chronic open-angle glaucoma with advanced to severe field loss according to modified Hodapp-Anderson-Parrish criteria on SITA 24-2 (Mills RP et al., 2006) and best-corrected visual acuity of 20/60 or better were enrolled in the present study. A comprehensive ophthalmologic evaluation was completed, and all patients performed the following tests of visual function: SITA 10-2 and Fine Matrix Mapping (FMM) perimetry on Humphrey visual fields, FDT-Matrix 10-2, and MR reading test (acuity, speed and critical print size on MNREAD Acuity Chart). Images of the optic disc were obtained with Confocal Scanning Laser Ophthalmoscope (CSLO HRTII) and images of the nerve fiber layer thickness (RNFL) were obtained with Optical Coherence Tomography (OCT, StratusOCT). Coefficients of determination (R2) were evaluated between tests of function and imaging. Data from one eye per participant were included in the analysis. Only good quality imaging data was included.

 
Results:
 

Table shows R2 (+P < 0.05, * P < 0.01, || P < 0.001). Greater proportion of variation around the mean was explained by models using measures of function from the central field with sectorial anatomical measures than standard 24-2 perimetry and global anatomical measures. FDT 10-2 showed the highest linear function-structure relationship for rim and RNFL followed by SITA 10-2. Acuity reading test and critical print size in particular correlated with temporal rim and RNFL.  

 
Conclusions:
 

Visual function tests that concentrate on the central field showed a higher correlation to global and temporal anatomical measures of rim and nerve fiber layer in advanced glaucoma patients. Visual fields of the central 10° and reading tests are likely to be better tools monitor for progression in advanced glaucoma patients.

 
Keywords: visual fields • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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