May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
The Long Term Stability of StratusOCT Reproducibility
Author Affiliations & Notes
  • W. D. Dilworth
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • T. Mumcuoglu
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • G. Wollstein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • L. Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • K. A. Townsend
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • R. A. Bilonick
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
  • H. Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • M. L. Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • J. S. Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept. of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Dept. of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships W.D. Dilworth, None; T. Mumcuoglu, None; G. Wollstein, Carl Zeiss Meditec, Inc., R; L. Kagemann, None; K.A. Townsend, None; R.A. Bilonick, None; H. Ishikawa, Carl Zeiss Meditec, Inc., R; M.L. Gabriele, None; J.S. Schuman, Alcon; Allergan; Carl Zeiss Meditec, Inc; Merck; Optoview; Heidelberg Engineering, F; Carl Zeiss Meditec, Inc., P; Alcon; Allergan; Carl Zeiss Meditec, Inc.; Clarity; Merck; Heidelberg Engineering, R.
  • Footnotes
    Support NIH contracts R01-EY13178-06 and P30-EY08098 (Bethesda, MD), The Eye and Ear Foundation (Pittsburgh, PA) and an unrestricted grant from Research to Prevent Blindness, Inc. (New York, NY)
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 520. doi:
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    • Get Citation

      W. D. Dilworth, T. Mumcuoglu, G. Wollstein, L. Kagemann, K. A. Townsend, R. A. Bilonick, H. Ishikawa, M. L. Gabriele, J. S. Schuman; The Long Term Stability of StratusOCT Reproducibility. Invest. Ophthalmol. Vis. Sci. 2007;48(13):520.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

Statistical design of longitudinal studies requires an estimation of measurement reproducibility over time. The purpose of the present study was to determine the stability of optical coherence tomography (OCT; StratusOCT, Carl Zeiss Meditec, Dublin, CA) retinal nerve fiber layer (RNFL) measurement reproducibility over time.

 
Methods:
 

One eye each in 11 subjects (5 male 6 female, 7 OD 4 OS, 39 ±;10 years of age) was examined using the StratusOCT fast RNFL scan protocol, consisting of an average of 3 circumpapillary scans, each with a diameter of 3.4 mm. Three fast RNFL scans with signal score>6 were obtained on each of 3 days within a month. This protocol was repeated after 12 months. Intervisit and intravisit interclass correlation (ICC) and standard deviation (SD) were calculated for mean RNFL, and each quadrant at year 1 and 2. The calibration of the imaging device was tested on a model eye on a monthly basis during both years, and the unit was routinely calibrated by the manufacturer between years 1 and 2.

 
Results:
 

The coefficients of variation (CVs) of the model eye measurements for years 1 and 2 were 0.29% and 0.32% respectively. The intervisit CVs of mean RNFL thickness were 1.29% and 1.20% for years 1 and 2 respectively.  

 
Conclusions:
 

Drift in the imaging device calibration may contribute to variability observed in patients. The reproducibility of mean RNFL measurements remains stable over one year; however, the reproducibility of RNFL measurements in individual quadrants varies. This should be taken into consideration when planning a longitudinal study.

 
Clinical Trial:
 

www.clinicaltrials.gov NCT00343746

 
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical • nerve fiber layer 
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