May 2007
Volume 48, Issue 13
ARVO Annual Meeting Abstract  |   May 2007
Dietary Omega -3 Fatty Acids and Neovascular Age Related Macular Degeneration: The Eureye Study
Author Affiliations & Notes
  • C. Augood
    Epidemiology & Population Hlth, London Sch of Hygiene & Trop Med, London, United Kingdom
  • U. Chakravarthy
    Ophthalmology and Vision Science, Queen's University Belfast, Belfast, United Kingdom
  • P. T. V. M. de Jong
    Netherlands Institute for Ophthalmic Research, Amsterdam, The Netherlands
  • M. Rahu
    National Institute for Health Development, Tallinn, Estonia
  • J. Seland
    Haukeland Sykehus, University of Bergen, Norway
  • G. Soubrane
    Clinique Ophthalmologique Universitaire de Creteil, Paris-Creteil, France
  • L. Tomazzoli
    Clinica Oculistica, Universita degli studi di Verona, Verona, Italy
  • F. Topouzis
    II Department of Ophthalmology, Aristotle University, Thessaloniki, Greece
  • J. Vioque
    Dpto Salud Publica, Universidad Miguel Hernandez, Alicante, Spain
  • A. E. Fletcher
    Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom
  • Footnotes
    Commercial Relationships C. Augood, None; U. Chakravarthy, None; P.T.V.M. de Jong, None; M. Rahu, None; J. Seland, None; G. Soubrane, None; L. Tomazzoli, None; F. Topouzis, None; J. Vioque, None; A.E. Fletcher, None.
  • Footnotes
    Support European Commission (QLK6-CT-1999-02094), Macular Disease Society UK, Thomas Pocklington Trust
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 1149. doi:
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      C. Augood, U. Chakravarthy, P. T. V. M. de Jong, M. Rahu, J. Seland, G. Soubrane, L. Tomazzoli, F. Topouzis, J. Vioque, A. E. Fletcher; Dietary Omega -3 Fatty Acids and Neovascular Age Related Macular Degeneration: The Eureye Study. Invest. Ophthalmol. Vis. Sci. 2007;48(13):1149.

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      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose:: To investigate whether oily fish and omega-3 fatty acids (docosahexaenoic acid- DHA- and eicosapentaenoic acid -EPA) in the diet of European elderly people is associated with neovascular age-related macular degeneration (NV-AMD).

Methods:: Participants in the seven country EUREYE study underwent fundus photography, and completed a food frequency questionnaire. Questionnaire data were converted to nutrients (including EPA and DHA) using food composition tables and adjusted for total energy intake. Survey logistic regression was used to investigate the association of quartiles of EPA or DHA with NV-AMD.

Results:: Dietary intake data and fundus images were available in 105 cases with neovascular AMD and in 2173 controls without any features of early or late AMD. In confounder adjusted analyses, eating oily fish at least once a week compared with less than once a week was associated with a halving of the odds of NV-AMD (OR=0.47, 95%CI 0.33-0.69, p=0.003). Compared to the lowest quartile there was a significant trend for decreased odds with increasing quartiles of either DHA or EPA. Odds ratios in the highest quartiles were OR=0.32, 95%CI 0.12-0.90, p=0.04 for DHA and OR=0.29, 95%CI 0.12-0.74, p=0.02 for EPA.

Conclusions:: Regular consumptions of marine oils may protect against neovascular AMD in older individuals.

Keywords: age-related macular degeneration • nutritional factors • clinical (human) or epidemiologic studies: risk factor assessment 

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